Flavonoid dihydroquercetin, unlike quercetin, fails to inhibit expression of heat shock proteins under conditions of cellular stress
Modification by natural flavonoids quercetin and dihydroquercetin of the in vitro cell response to hyperthermal and chemical stress was studied. Quercetin completely inhibited the synthesis and intracellular accumulation of 70-kD heat shock protein (HSP70) in response to hyperthermia or to treatment...
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| Veröffentlicht in: | Biochemistry (Moscow) 2003-09, Vol.68 (9), p.1055-1061 |
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| container_title | Biochemistry (Moscow) |
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| creator | Budagova, K R Zhmaeva, S V Grigor'ev, A N Goncharova, A Ya Kabakov, A E |
| description | Modification by natural flavonoids quercetin and dihydroquercetin of the in vitro cell response to hyperthermal and chemical stress was studied. Quercetin completely inhibited the synthesis and intracellular accumulation of 70-kD heat shock protein (HSP70) in response to hyperthermia or to treatment with sodium arsenite, whereas dihydroquercetin in the same or higher doses had no such effect. Stress exposures under conditions of the quercetin-inhibited HSP70 expression significantly increased the percentage of dead and damaged cells compared to the same exposures in the absence of quercetin. On the contrary, dihydroquercetin virtually failed to increase the damage and death of the stress-exposed cells which displayed typical induction of HSP70. The findings suggest a new strategy for pharmacological use of these flavonoids with similar structure. |
| doi_str_mv | 10.1023/A:1026081016923 |
| format | Article |
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Quercetin completely inhibited the synthesis and intracellular accumulation of 70-kD heat shock protein (HSP70) in response to hyperthermia or to treatment with sodium arsenite, whereas dihydroquercetin in the same or higher doses had no such effect. Stress exposures under conditions of the quercetin-inhibited HSP70 expression significantly increased the percentage of dead and damaged cells compared to the same exposures in the absence of quercetin. On the contrary, dihydroquercetin virtually failed to increase the damage and death of the stress-exposed cells which displayed typical induction of HSP70. The findings suggest a new strategy for pharmacological use of these flavonoids with similar structure.</description><identifier>ISSN: 0006-2979</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1023/A:1026081016923</identifier><identifier>PMID: 14606951</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Cell Line ; Cell Size - drug effects ; Endothelial Cells - cytology ; Endothelial Cells - drug effects ; Flavonoids ; Flavonoids - chemistry ; Flavonoids - pharmacology ; Flavonols - chemistry ; Flavonols - pharmacology ; Gene Expression Regulation - drug effects ; Heat-Shock Response - drug effects ; HSP70 Heat-Shock Proteins - metabolism ; Mice ; Molecular Structure ; Proteins ; Quercetin - analogs & derivatives ; Quercetin - chemistry ; Quercetin - pharmacology ; Sodium arsenite</subject><ispartof>Biochemistry (Moscow), 2003-09, Vol.68 (9), p.1055-1061</ispartof><rights>MAIK "Nauka/Interperiodica" 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-a147b777c6449cf280ad5ceca833d4de9dab0a74f0d7860fdee3b027e67d8b5e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14606951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Budagova, K R</creatorcontrib><creatorcontrib>Zhmaeva, S V</creatorcontrib><creatorcontrib>Grigor'ev, A N</creatorcontrib><creatorcontrib>Goncharova, A Ya</creatorcontrib><creatorcontrib>Kabakov, A E</creatorcontrib><title>Flavonoid dihydroquercetin, unlike quercetin, fails to inhibit expression of heat shock proteins under conditions of cellular stress</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry (Mosc)</addtitle><description>Modification by natural flavonoids quercetin and dihydroquercetin of the in vitro cell response to hyperthermal and chemical stress was studied. Quercetin completely inhibited the synthesis and intracellular accumulation of 70-kD heat shock protein (HSP70) in response to hyperthermia or to treatment with sodium arsenite, whereas dihydroquercetin in the same or higher doses had no such effect. Stress exposures under conditions of the quercetin-inhibited HSP70 expression significantly increased the percentage of dead and damaged cells compared to the same exposures in the absence of quercetin. On the contrary, dihydroquercetin virtually failed to increase the damage and death of the stress-exposed cells which displayed typical induction of HSP70. 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| subjects | Animals Cell Line Cell Size - drug effects Endothelial Cells - cytology Endothelial Cells - drug effects Flavonoids Flavonoids - chemistry Flavonoids - pharmacology Flavonols - chemistry Flavonols - pharmacology Gene Expression Regulation - drug effects Heat-Shock Response - drug effects HSP70 Heat-Shock Proteins - metabolism Mice Molecular Structure Proteins Quercetin - analogs & derivatives Quercetin - chemistry Quercetin - pharmacology Sodium arsenite |
| title | Flavonoid dihydroquercetin, unlike quercetin, fails to inhibit expression of heat shock proteins under conditions of cellular stress |
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