Concentration-independent spontaneously forming biomimetric vesicles

Concentration-independent spontaneously forming biomimetric vesicles

In this Letter we present small-angle neutron scattering data from a biomimetic system composed of the phospholipids dimyristoyl and dihexanoyl phosphorylcholine (DMPC and DHPC, respectively). Doping DMPC-DHPC multilamellar vesicles with either the negatively charged lipid dimyristoyl phosphorylglyc...

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Veröffentlicht in:Physical review letters 2003-10, Vol.91 (15), p.158105-158105, Article 158105
Hauptverfasser: Nieh, M-P, Harroun, T A, Raghunathan, V A, Glinka, C J, Katsaras, J
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Sprache:eng
Schlagworte:
Biomimetic Materials - chemistry
Calcium - chemistry
Cations, Divalent
Dimyristoylphosphatidylcholine - chemistry
Kinetics
Liposomes - chemistry
Phospholipid Ethers - chemistry
Thermodynamics
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container_end_page 158105
container_issue 15
container_start_page 158105
container_title Physical review letters
container_volume 91
creator Nieh, M-P
Harroun, T A
Raghunathan, V A
Glinka, C J
Katsaras, J
description In this Letter we present small-angle neutron scattering data from a biomimetic system composed of the phospholipids dimyristoyl and dihexanoyl phosphorylcholine (DMPC and DHPC, respectively). Doping DMPC-DHPC multilamellar vesicles with either the negatively charged lipid dimyristoyl phosphorylglycerol (DMPG, net charge -1) or the divalent cation, calcium (Ca2+), leads to the spontaneous formation of energetically stabilized monodisperse unilamellar vesicles whose radii are concentration independent and in contrast with previous experimental observations.
doi_str_mv 10.1103/PhysRevLett.91.158105
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subjects Biomimetic Materials - chemistry
Calcium - chemistry
Cations, Divalent
Dimyristoylphosphatidylcholine - chemistry
Kinetics
Liposomes - chemistry
Phospholipid Ethers - chemistry
Thermodynamics
title Concentration-independent spontaneously forming biomimetric vesicles
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