Control of neuronal nitric oxide synthase and brain-derived neurotrophic factor levels by GABA-A receptors in the developing rat cortex

Gamma-aminobutyric acid (GABA) plays an important morphogenetic role, acting through GABA-A receptors, which are depolarizing in the developing rat brain. Other molecules with major morphogenetic roles are the nitric oxide free radical (NO ·) and brain-derived neurotrophic factor (BDNF), both of whi...

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Veröffentlicht in:	Brain research. Developmental brain research 2003-11, Vol.145 (2), p.185-195
Hauptverfasser:	Mantelas, A, Stamatakis, A, Kazanis, I, Philippidis, H, Stylianopoulou, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn BDNF Brain-Derived Neurotrophic Factor - metabolism Calcium Channel Blockers - pharmacology Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - metabolism Calcium Signaling - physiology Cell Differentiation - drug effects Cell Differentiation - physiology Cerebral Cortex - cytology Cerebral Cortex - growth & development Cerebral Cortex - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Diazepam Diazepam - pharmacology Female GABA GABA Modulators - pharmacology GABA-A Receptor Agonists Humans L-type voltage-gated Ca 2+ channel (L-type VGCC) Male Membrane Potentials - physiology Neurons - cytology Neurons - drug effects Neurons - metabolism Nitric Oxide - biosynthesis Nitric Oxide Synthase - metabolism nNOS pCREB Phosphorylation Rats Rats, Wistar Receptors, GABA-A - metabolism
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