Menatetrenone ameliorates reduction in bone mineral density and bone strength in sciatic neurectomized rats
Summary Vitamin K2 (menaquinone) acts on the bone metabolism. Menatetrenon (MK-4) is a vitamin K2 homologue that has been used as a therapeutic agent for osteoporosis in Japan. Rat models of immobilization induced by sciatic neurectomy are characterized by transiently increased bone resorption and s...
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| Veröffentlicht in: | Journal of Nutritional Science and Vitaminology 2003, Vol.49(4), pp.256-261 |
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| container_title | Journal of Nutritional Science and Vitaminology |
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| creator | Iwasaki Ishizuka, Y. (Oita Univ. of Nursing and Health Sciences (Japan)) Yamato, H Murayama, H Abe, M Takahashi, K Kurokawa, K Fukagawa, M Ezawa, I |
| description | Summary Vitamin K2 (menaquinone) acts on the bone metabolism. Menatetrenon (MK-4) is a vitamin K2 homologue that has been used as a therapeutic agent for osteoporosis in Japan. Rat models of immobilization induced by sciatic neurectomy are characterized by transiently increased bone resorption and sustained reduction in bone formation. Using such a rat model, we investigated the efficacy of MK-4 on bone loss. Male Sprague-Dawley rats were subjected to unilateral sciatic neurectomy and administered MK-4 for 28 d beginning day 21 after operation. The effect of MK-4 on the immobilized bone was assessed by measuring the bone mineral density of the femur, breaking force of the femoral diaphysis, and bone histomorphometry in tibial diaphysis. The BMD on both the femoral distal metaphysis and diaphysis was reduced by sciatic neurectomy. The administration of MK-4 ameliorated this reduction in a dose-dependent manner. The administration of 30 mg/kg MK-4 ameliorated the reduction in bone strength. An improvement in bone formation was observed following the administration of MK-4. These results suggest that MK-4 has a therapeutic potential for immobilization-induced osteopenia. |
| doi_str_mv | 10.3177/jnsv.49.256 |
| format | Article |
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(Oita Univ. of Nursing and Health Sciences (Japan)) ; Yamato, H ; Murayama, H ; Abe, M ; Takahashi, K ; Kurokawa, K ; Fukagawa, M ; Ezawa, I</creator><creatorcontrib>Iwasaki Ishizuka, Y. (Oita Univ. of Nursing and Health Sciences (Japan)) ; Yamato, H ; Murayama, H ; Abe, M ; Takahashi, K ; Kurokawa, K ; Fukagawa, M ; Ezawa, I</creatorcontrib><description>Summary Vitamin K2 (menaquinone) acts on the bone metabolism. Menatetrenon (MK-4) is a vitamin K2 homologue that has been used as a therapeutic agent for osteoporosis in Japan. Rat models of immobilization induced by sciatic neurectomy are characterized by transiently increased bone resorption and sustained reduction in bone formation. Using such a rat model, we investigated the efficacy of MK-4 on bone loss. Male Sprague-Dawley rats were subjected to unilateral sciatic neurectomy and administered MK-4 for 28 d beginning day 21 after operation. The effect of MK-4 on the immobilized bone was assessed by measuring the bone mineral density of the femur, breaking force of the femoral diaphysis, and bone histomorphometry in tibial diaphysis. The BMD on both the femoral distal metaphysis and diaphysis was reduced by sciatic neurectomy. The administration of MK-4 ameliorated this reduction in a dose-dependent manner. The administration of 30 mg/kg MK-4 ameliorated the reduction in bone strength. An improvement in bone formation was observed following the administration of MK-4. These results suggest that MK-4 has a therapeutic potential for immobilization-induced osteopenia.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.49.256</identifier><identifier>PMID: 14598912</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>Absorptiometry, Photon ; Animals ; Biological and medical sciences ; Bone Density - drug effects ; bone mineral density ; Bone Resorption - prevention & control ; bone strength ; BONES ; Bones, joints and connective tissue. Antiinflammatory agents ; cortical bone ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Immobilization ; Male ; Medical sciences ; menatetrenone ; MINERAL NUTRIENTS ; Osteoporosis - drug therapy ; Pharmacology. Drug treatments ; RATS ; Rats, Sprague-Dawley ; Sciatic Nerve - physiology ; Sciatic Nerve - surgery ; sciatic neurectomy ; STRENGTH ; Tensile Strength - drug effects ; VITAMIN K ; Vitamin K 2 - analogs & derivatives ; Vitamin K 2 - pharmacology</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2003, Vol.49(4), pp.256-261</ispartof><rights>the Center for Academic Publications Japan</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c607t-62055d768ffa38a686488910a63df53b2a7159f52c50dccd968ae733768589bf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15182761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14598912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwasaki Ishizuka, Y. (Oita Univ. of Nursing and Health Sciences (Japan))</creatorcontrib><creatorcontrib>Yamato, H</creatorcontrib><creatorcontrib>Murayama, H</creatorcontrib><creatorcontrib>Abe, M</creatorcontrib><creatorcontrib>Takahashi, K</creatorcontrib><creatorcontrib>Kurokawa, K</creatorcontrib><creatorcontrib>Fukagawa, M</creatorcontrib><creatorcontrib>Ezawa, I</creatorcontrib><title>Menatetrenone ameliorates reduction in bone mineral density and bone strength in sciatic neurectomized rats</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>Summary Vitamin K2 (menaquinone) acts on the bone metabolism. Menatetrenon (MK-4) is a vitamin K2 homologue that has been used as a therapeutic agent for osteoporosis in Japan. Rat models of immobilization induced by sciatic neurectomy are characterized by transiently increased bone resorption and sustained reduction in bone formation. Using such a rat model, we investigated the efficacy of MK-4 on bone loss. Male Sprague-Dawley rats were subjected to unilateral sciatic neurectomy and administered MK-4 for 28 d beginning day 21 after operation. The effect of MK-4 on the immobilized bone was assessed by measuring the bone mineral density of the femur, breaking force of the femoral diaphysis, and bone histomorphometry in tibial diaphysis. The BMD on both the femoral distal metaphysis and diaphysis was reduced by sciatic neurectomy. The administration of MK-4 ameliorated this reduction in a dose-dependent manner. The administration of 30 mg/kg MK-4 ameliorated the reduction in bone strength. An improvement in bone formation was observed following the administration of MK-4. These results suggest that MK-4 has a therapeutic potential for immobilization-induced osteopenia.</description><subject>Absorptiometry, Photon</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Density - drug effects</subject><subject>bone mineral density</subject><subject>Bone Resorption - prevention & control</subject><subject>bone strength</subject><subject>BONES</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>cortical bone</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Immobilization</subject><subject>Male</subject><subject>Medical sciences</subject><subject>menatetrenone</subject><subject>MINERAL NUTRIENTS</subject><subject>Osteoporosis - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>Sciatic Nerve - physiology</subject><subject>Sciatic Nerve - surgery</subject><subject>sciatic neurectomy</subject><subject>STRENGTH</subject><subject>Tensile Strength - drug effects</subject><subject>VITAMIN K</subject><subject>Vitamin K 2 - analogs & derivatives</subject><subject>Vitamin K 2 - pharmacology</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtv1DAUhS1ERYfCijUoG9igDHb8zBKVV6siWMDauuPcTD0kTms7lcqvxyGjVrJsyee751jHhLxidMuZ1h8OId1tRbttpHpCNswYVmstmqdkQzlltTCUnpLnKR0oFa0R5hk5ZUK2pmXNhvz5jgEy5ohhCljBiIOfYrlJVcRudtlPofKh2i3q6ANGGKoOQ_L5voLQrUJa5vf5eiGT85C9qwLOEV2eRv8Xu6pYphfkpIch4cvjeUZ-f_n86_xbffXj68X5x6vaKapzrRoqZaeV6XvgBpRRwpTHUlC86yXfNaCZbHvZOEk757pWGUDNeZmQpt31_Iy8W31v4nQ7Y8p29MnhMEDAaU5WMy6U5qqA71fQxSmliL29iX6EeG8ZtUu3dunWitaWbgv95mg770bsHtljmQV4ewQgORj6CMH59MhJZhqtWOE-rdwhZdjjAwCx9Dbg_1DWar4Ei3Ur-Q-yu4ZoMRSb16tND5OFfSxRlz-b8sllMSb5P8mKpOM</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Iwasaki Ishizuka, Y. (Oita Univ. of Nursing and Health Sciences (Japan))</creator><creator>Yamato, H</creator><creator>Murayama, H</creator><creator>Abe, M</creator><creator>Takahashi, K</creator><creator>Kurokawa, K</creator><creator>Fukagawa, M</creator><creator>Ezawa, I</creator><general>Center for Academic Publications Japan</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>Menatetrenone ameliorates reduction in bone mineral density and bone strength in sciatic neurectomized rats</title><author>Iwasaki Ishizuka, Y. (Oita Univ. of Nursing and Health Sciences (Japan)) ; Yamato, H ; Murayama, H ; Abe, M ; Takahashi, K ; Kurokawa, K ; Fukagawa, M ; Ezawa, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c607t-62055d768ffa38a686488910a63df53b2a7159f52c50dccd968ae733768589bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Absorptiometry, Photon</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Density - drug effects</topic><topic>bone mineral density</topic><topic>Bone Resorption - prevention & control</topic><topic>bone strength</topic><topic>BONES</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>cortical bone</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Immobilization</topic><topic>Male</topic><topic>Medical sciences</topic><topic>menatetrenone</topic><topic>MINERAL NUTRIENTS</topic><topic>Osteoporosis - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>Sciatic Nerve - physiology</topic><topic>Sciatic Nerve - surgery</topic><topic>sciatic neurectomy</topic><topic>STRENGTH</topic><topic>Tensile Strength - drug effects</topic><topic>VITAMIN K</topic><topic>Vitamin K 2 - analogs & derivatives</topic><topic>Vitamin K 2 - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwasaki Ishizuka, Y. (Oita Univ. of Nursing and Health Sciences (Japan))</creatorcontrib><creatorcontrib>Yamato, H</creatorcontrib><creatorcontrib>Murayama, H</creatorcontrib><creatorcontrib>Abe, M</creatorcontrib><creatorcontrib>Takahashi, K</creatorcontrib><creatorcontrib>Kurokawa, K</creatorcontrib><creatorcontrib>Fukagawa, M</creatorcontrib><creatorcontrib>Ezawa, I</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwasaki Ishizuka, Y. (Oita Univ. of Nursing and Health Sciences (Japan))</au><au>Yamato, H</au><au>Murayama, H</au><au>Abe, M</au><au>Takahashi, K</au><au>Kurokawa, K</au><au>Fukagawa, M</au><au>Ezawa, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Menatetrenone ameliorates reduction in bone mineral density and bone strength in sciatic neurectomized rats</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2003</date><risdate>2003</risdate><volume>49</volume><issue>4</issue><spage>256</spage><epage>261</epage><pages>256-261</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>Summary Vitamin K2 (menaquinone) acts on the bone metabolism. Menatetrenon (MK-4) is a vitamin K2 homologue that has been used as a therapeutic agent for osteoporosis in Japan. Rat models of immobilization induced by sciatic neurectomy are characterized by transiently increased bone resorption and sustained reduction in bone formation. Using such a rat model, we investigated the efficacy of MK-4 on bone loss. Male Sprague-Dawley rats were subjected to unilateral sciatic neurectomy and administered MK-4 for 28 d beginning day 21 after operation. The effect of MK-4 on the immobilized bone was assessed by measuring the bone mineral density of the femur, breaking force of the femoral diaphysis, and bone histomorphometry in tibial diaphysis. The BMD on both the femoral distal metaphysis and diaphysis was reduced by sciatic neurectomy. The administration of MK-4 ameliorated this reduction in a dose-dependent manner. The administration of 30 mg/kg MK-4 ameliorated the reduction in bone strength. An improvement in bone formation was observed following the administration of MK-4. These results suggest that MK-4 has a therapeutic potential for immobilization-induced osteopenia.</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>14598912</pmid><doi>10.3177/jnsv.49.256</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absorptiometry, Photon Animals Biological and medical sciences Bone Density - drug effects bone mineral density Bone Resorption - prevention & control bone strength BONES Bones, joints and connective tissue. Antiinflammatory agents cortical bone Disease Models, Animal Dose-Response Relationship, Drug Immobilization Male Medical sciences menatetrenone MINERAL NUTRIENTS Osteoporosis - drug therapy Pharmacology. Drug treatments RATS Rats, Sprague-Dawley Sciatic Nerve - physiology Sciatic Nerve - surgery sciatic neurectomy STRENGTH Tensile Strength - drug effects VITAMIN K Vitamin K 2 - analogs & derivatives Vitamin K 2 - pharmacology |
| title | Menatetrenone ameliorates reduction in bone mineral density and bone strength in sciatic neurectomized rats |
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