Fine-needle aspiration biopsy of the thyroid in an area of endemic goitre: influence of restored sufficient iodine supplementation on the clinical significance of cytological results
The iodine status of the population of Poland has markedly improved over the past years. The aims of this paper were: (i) to examine the diagnostic value of fine-needle aspiration biopsy (FNAB) of the thyroid in goitre endemic regions (in conditions of improved iodine supply), and (ii) to find wheth...
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| Veröffentlicht in: | European journal of endocrinology 2002, Vol.146 (1), p.19-26 |
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| container_title | European journal of endocrinology |
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| creator | SŁOWINSKA-KLENCKA, Dorota KLENCKI, Mariusz SPORNY, Stanisław LEWINSKI, Andrzej |
| description | The iodine status of the population of Poland has markedly improved over the past years. The aims of this paper were: (i) to examine the diagnostic value of fine-needle aspiration biopsy (FNAB) of the thyroid in goitre endemic regions (in conditions of improved iodine supply), and (ii) to find whether the changes in iodine supply have already influenced the clinical interpretation of cytological results.
Cytological diagnoses, based on 3782 aspirates, obtained from 3572 patients during the years 1985-1999, were verified by reference to the results of postoperative examinations. The relative occurrences of selected cytological results in 1992-1999 were also compared (patients not subjected to surgery were included).
We have found that the frequency of neoplastic lesions significantly decreased throughout the examined period (P |
| doi_str_mv | 10.1530/eje.0.1460019 |
| format | Article |
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Cytological diagnoses, based on 3782 aspirates, obtained from 3572 patients during the years 1985-1999, were verified by reference to the results of postoperative examinations. The relative occurrences of selected cytological results in 1992-1999 were also compared (patients not subjected to surgery were included).
We have found that the frequency of neoplastic lesions significantly decreased throughout the examined period (P<0.02). The ratio of the papillary carcinoma frequency to the follicular carcinoma frequency increased from 1.7 during 1992-1993 up to 8.0 during 1998-1999 (P<0.05). The frequency of cytologically diagnosed chronic thyroiditis increased from 1.5% in 1992 to 5.7% in 1999 (P<0.001); the percentage of cytological diagnosis of "follicular neoplasm" decreased during the same time (P<0.001). The risk of malignancy significantly lowered in the cytological diagnoses of "follicular neoplasm" from 15% during 1985-1993 to 6% during 1996-1999 (P<0.05).
The diagnostic value of FNAB during the period without proper iodine prophylaxis did not differ significantly from that during the last examined period. However, the changes in iodine supply have markedly and promptly affected the clinical significance of particular cytological results.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/eje.0.1460019</identifier><identifier>PMID: 11751062</identifier><language>eng</language><publisher>Colchester: Portland Press</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biopsy, Needle ; Carcinoma, Papillary, Follicular - epidemiology ; Child ; Diet ; Endocrinopathies ; Female ; Goiter, Endemic - diet therapy ; Goiter, Endemic - epidemiology ; Goiter, Endemic - pathology ; Humans ; Iodine - therapeutic use ; Male ; Malignant tumors ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Poland - epidemiology ; Risk ; Thyroid Gland - pathology ; Thyroid Neoplasms ; Thyroid. Thyroid axis (diseases) ; Thyroiditis, Autoimmune - diagnosis ; Thyroiditis, Autoimmune - epidemiology</subject><ispartof>European journal of endocrinology, 2002, Vol.146 (1), p.19-26</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-5bab957787798d92c133d5485af722b1d42591b511791e7b31e482e0d547ea593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13444169$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11751062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SŁOWINSKA-KLENCKA, Dorota</creatorcontrib><creatorcontrib>KLENCKI, Mariusz</creatorcontrib><creatorcontrib>SPORNY, Stanisław</creatorcontrib><creatorcontrib>LEWINSKI, Andrzej</creatorcontrib><title>Fine-needle aspiration biopsy of the thyroid in an area of endemic goitre: influence of restored sufficient iodine supplementation on the clinical significance of cytological results</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>The iodine status of the population of Poland has markedly improved over the past years. The aims of this paper were: (i) to examine the diagnostic value of fine-needle aspiration biopsy (FNAB) of the thyroid in goitre endemic regions (in conditions of improved iodine supply), and (ii) to find whether the changes in iodine supply have already influenced the clinical interpretation of cytological results.
Cytological diagnoses, based on 3782 aspirates, obtained from 3572 patients during the years 1985-1999, were verified by reference to the results of postoperative examinations. The relative occurrences of selected cytological results in 1992-1999 were also compared (patients not subjected to surgery were included).
We have found that the frequency of neoplastic lesions significantly decreased throughout the examined period (P<0.02). The ratio of the papillary carcinoma frequency to the follicular carcinoma frequency increased from 1.7 during 1992-1993 up to 8.0 during 1998-1999 (P<0.05). The frequency of cytologically diagnosed chronic thyroiditis increased from 1.5% in 1992 to 5.7% in 1999 (P<0.001); the percentage of cytological diagnosis of "follicular neoplasm" decreased during the same time (P<0.001). The risk of malignancy significantly lowered in the cytological diagnoses of "follicular neoplasm" from 15% during 1985-1993 to 6% during 1996-1999 (P<0.05).
The diagnostic value of FNAB during the period without proper iodine prophylaxis did not differ significantly from that during the last examined period. However, the changes in iodine supply have markedly and promptly affected the clinical significance of particular cytological results.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Carcinoma, Papillary, Follicular - epidemiology</subject><subject>Child</subject><subject>Diet</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Goiter, Endemic - diet therapy</subject><subject>Goiter, Endemic - epidemiology</subject><subject>Goiter, Endemic - pathology</subject><subject>Humans</subject><subject>Iodine - therapeutic use</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Poland - epidemiology</subject><subject>Risk</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Neoplasms</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyroiditis, Autoimmune - diagnosis</subject><subject>Thyroiditis, Autoimmune - epidemiology</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc-L1TAQx4Mo7nP16FVy0VvX_Gxab7K4Kix4UfBW0mT6zJImNWkP7x_bv895vsJCQoaZT77DzJeQt5zdcC3ZR3iAGwxVyxjvn5EDV6Zv2k7-fk4OrGOqUa2SV-RVrQ9IYMxekivOjeasFQfyeBcSNAnAR6C2LqHYNeREx5CXeqJ5ousfwHsqOXgaErV4CthzBZKHOTh6zGEt8AmrU9wgOTgXC9Q1F_C0btMUXIC00pA9dsPMskSYMXPphefcxMWQgrOR1nBMAf_YXcqd1hzz8X8NZbe41tfkxWRjhTf7e01-3X35efutuf_x9fvt5_vGya5dGz3asdfGdMb0ne-F41J6rTptJyPEyL0Suuejxn30HMwoOahOAEPGgNW9vCYfLrpLyX83HGmYQ3UQo02QtzoYLlUrhECwuYCu5FoLTMNSwmzLaeBsOBs1oFEDhhejkH-3C2_jDP6J3p1B4P0O2IqDTwW3EeoTJ5VSvO3lP-mCn0s</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>SŁOWINSKA-KLENCKA, Dorota</creator><creator>KLENCKI, Mariusz</creator><creator>SPORNY, Stanisław</creator><creator>LEWINSKI, Andrzej</creator><general>Portland Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2002</creationdate><title>Fine-needle aspiration biopsy of the thyroid in an area of endemic goitre: influence of restored sufficient iodine supplementation on the clinical significance of cytological results</title><author>SŁOWINSKA-KLENCKA, Dorota ; KLENCKI, Mariusz ; SPORNY, Stanisław ; LEWINSKI, Andrzej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-5bab957787798d92c133d5485af722b1d42591b511791e7b31e482e0d547ea593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Carcinoma, Papillary, Follicular - epidemiology</topic><topic>Child</topic><topic>Diet</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Goiter, Endemic - diet therapy</topic><topic>Goiter, Endemic - epidemiology</topic><topic>Goiter, Endemic - pathology</topic><topic>Humans</topic><topic>Iodine - therapeutic use</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Poland - epidemiology</topic><topic>Risk</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Neoplasms</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyroiditis, Autoimmune - diagnosis</topic><topic>Thyroiditis, Autoimmune - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SŁOWINSKA-KLENCKA, Dorota</creatorcontrib><creatorcontrib>KLENCKI, Mariusz</creatorcontrib><creatorcontrib>SPORNY, Stanisław</creatorcontrib><creatorcontrib>LEWINSKI, Andrzej</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SŁOWINSKA-KLENCKA, Dorota</au><au>KLENCKI, Mariusz</au><au>SPORNY, Stanisław</au><au>LEWINSKI, Andrzej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fine-needle aspiration biopsy of the thyroid in an area of endemic goitre: influence of restored sufficient iodine supplementation on the clinical significance of cytological results</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2002</date><risdate>2002</risdate><volume>146</volume><issue>1</issue><spage>19</spage><epage>26</epage><pages>19-26</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>The iodine status of the population of Poland has markedly improved over the past years. The aims of this paper were: (i) to examine the diagnostic value of fine-needle aspiration biopsy (FNAB) of the thyroid in goitre endemic regions (in conditions of improved iodine supply), and (ii) to find whether the changes in iodine supply have already influenced the clinical interpretation of cytological results.
Cytological diagnoses, based on 3782 aspirates, obtained from 3572 patients during the years 1985-1999, were verified by reference to the results of postoperative examinations. The relative occurrences of selected cytological results in 1992-1999 were also compared (patients not subjected to surgery were included).
We have found that the frequency of neoplastic lesions significantly decreased throughout the examined period (P<0.02). The ratio of the papillary carcinoma frequency to the follicular carcinoma frequency increased from 1.7 during 1992-1993 up to 8.0 during 1998-1999 (P<0.05). The frequency of cytologically diagnosed chronic thyroiditis increased from 1.5% in 1992 to 5.7% in 1999 (P<0.001); the percentage of cytological diagnosis of "follicular neoplasm" decreased during the same time (P<0.001). The risk of malignancy significantly lowered in the cytological diagnoses of "follicular neoplasm" from 15% during 1985-1993 to 6% during 1996-1999 (P<0.05).
The diagnostic value of FNAB during the period without proper iodine prophylaxis did not differ significantly from that during the last examined period. However, the changes in iodine supply have markedly and promptly affected the clinical significance of particular cytological results.</abstract><cop>Colchester</cop><pub>Portland Press</pub><pmid>11751062</pmid><doi>10.1530/eje.0.1460019</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adolescent Adult Aged Biological and medical sciences Biopsy, Needle Carcinoma, Papillary, Follicular - epidemiology Child Diet Endocrinopathies Female Goiter, Endemic - diet therapy Goiter, Endemic - epidemiology Goiter, Endemic - pathology Humans Iodine - therapeutic use Male Malignant tumors Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Poland - epidemiology Risk Thyroid Gland - pathology Thyroid Neoplasms Thyroid. Thyroid axis (diseases) Thyroiditis, Autoimmune - diagnosis Thyroiditis, Autoimmune - epidemiology |
| title | Fine-needle aspiration biopsy of the thyroid in an area of endemic goitre: influence of restored sufficient iodine supplementation on the clinical significance of cytological results |
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