Quantification of crystalline forms in active pharmaceutical ingredient and tablets by X-ray powder diffraction

ABSTRACT A Merck development compound was known to exist in several polymorphic forms, hydrates and solvates. The polymorphic forms were characterized and the most thermodynamically stable form at room temperature was identified and taken into development. During routine stability analysis it became...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2003-09, Vol.55 (9), p.1323-1329
Hauptverfasser:	Cooper, V. Brett, Pearce, Gareth E. S., Petts, Catherine R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Crystallization Crystallography, X-Ray - methods Drug Stability Drug Storage - methods General pharmacology Medical sciences Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Reproducibility of Results Tablets - analysis Tablets - chemistry Technology, Pharmaceutical - methods
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