Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation

We evaluated the role of spinal glutamate and substance P receptors in noxious stimulus-induced antinociception (NSIA). NSIA was produced by subdermal capsaicin administration in the hind paw of the rat and measured as attenuation of the jaw-opening reflex. NSIA was completely blocked by spinal intr...

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Veröffentlicht in:	Pain (Amsterdam) 2003-11, Vol.106 (1), p.173-179
Hauptverfasser:	Tambeli, Claudia H, Young, Andrew, Levine, Jon D, Gear, Robert W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoates - pharmacology Biological and medical sciences Capsaicin Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Glutamate Glutamic Acid - physiology Glycine - analogs & derivatives Glycine - pharmacology Isoquinolines - pharmacology Male NMDA and mGluR 5 receptors Nociceptors - drug effects Nociceptors - physiology Noxious stimulus-induced antinociception Pyridines - pharmacology Quinoxalines - pharmacology Quinuclidines - pharmacology Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - physiology Receptors, N-Methyl-D-Aspartate - physiology Receptors, Neurokinin-1 - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - physiology Stimulation, Chemical Substance P - physiology Vertebrates: nervous system and sense organs
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