Evidence for a tonic GABA-ergic inhibition of excitatory respiratory-related afferents to presympathetic neurons in the rostral ventrolateral medulla

The effect of blockade of ionotropic GABA and glutamate receptors in the rostral ventrolateral medulla (RVLM) on the relationship between phrenic nerve, splanchnic sympathetic nerve and lumbar sympathetic nerve activities was examined in urethane anesthetized, paralyzed and vagotomized Sprague–Dawle...

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Veröffentlicht in:	Brain research 2002-01, Vol.924 (1), p.56-62
Hauptverfasser:	Miyawaki, Takashi, Goodchild, Ann K, Pilowsky, Paul M
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Afferent Pathways - drug effects Afferent Pathways - metabolism Animals Baroreceptor reflex Bicuculline - pharmacology Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology gamma-Aminobutyric Acid - metabolism Glutamate Glutamic Acid - metabolism Glycine Interneurons - drug effects Interneurons - metabolism Kynurenic Acid - pharmacology Male Medulla Oblongata - drug effects Medulla Oblongata - metabolism Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Neural Inhibition - drug effects Neural Inhibition - physiology phrenic nerve Phrenic Nerve - drug effects Phrenic Nerve - physiology Phrenic nerve discharge Rats Rats, Sprague-Dawley Respiratory Center - drug effects Respiratory Center - metabolism Respiratory Physiological Phenomena - drug effects Respiratory rhythm Splanchnic Nerves - drug effects Splanchnic Nerves - physiology Sympathetic nerve activity Sympathetic Nervous System - drug effects Sympathetic Nervous System - metabolism Vertebrates: nervous system and sense organs
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