Inhibition of fibrinolysis by recombinant factor VIIa in plasma from patients with severe hemophilia A

Recombinant factor VIIa (rFVIIa) is a novel prohemostatic drug for patients with hemophilia who have developed inhibitory antibodies. The postulation has been made that hemophilia is not only a disorder of coagulation, but that hyperfibrinolysis due to a defective activation of thrombin activatable...

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Veröffentlicht in:	Blood 2002-01, Vol.99 (1), p.175-179
Hauptverfasser:	Lisman, Ton, Mosnier, Laurent O., Lambert, Thierry, Mauser-Bunschoten, Evelien P., Meijers, Joost C.M., Nieuwenhuis, H. Karel, de Groot, Philip G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - pharmacology Biological and medical sciences Blood Coagulation - drug effects Blood Proteins - analysis Blood. Blood coagulation. Reticuloendothelial system Carboxypeptidase B2 - physiology Factor VIIa - administration & dosage Factor VIIa - pharmacology Factor VIII - physiology Fibrinolysis - drug effects Fibrinolytic Agents Hemophilia A - blood Humans Lipoproteins - antagonists & inhibitors Lipoproteins - physiology Medical sciences Pharmacology. Drug treatments Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacology Thromboplastin - antagonists & inhibitors Thromboplastin - physiology Time Factors
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