Gene expression profiling of aging using DNA microarrays

We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated...

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Veröffentlicht in:	Mechanisms of ageing and development 2002, Vol.123 (2), p.177-193
Hauptverfasser:	Weindruch, Richard, Kayo, Tsuyoshi, Lee, Cheol-Koo, Prolla, Tomas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - metabolism Animals Biological and medical sciences Brain Caloric restriction Development. Metamorphosis. Moult. Ageing DNA microarrays Energy Intake Fundamental and applied biological sciences. Psychology Gene Expression Gene Expression Profiling Macromolecular Substances Male Mice Mice, Inbred C57BL Muscle Muscle, Skeletal - metabolism Oligonucleotide Array Sequence Analysis - methods Proteins - metabolism Transcription, Genetic Vertebrates: anatomy and physiology, studies on body, several organs or systems
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