Mitochondrial DNA mutations in human colonic crypt stem cells

The mitochondrial genome encodes 13 essential subunits of the respiratory chain and has remarkable genetics based on uniparental inheritance. Within human populations, the mitochondrial genome has a high rate of sequence divergence with multiple polymorphic variants and thus has played a major role...

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Veröffentlicht in:	The Journal of clinical investigation 2003-11, Vol.112 (9), p.1351-1360
Hauptverfasser:	Taylor, Robert W, Barron, Martin J, Borthwick, Gillian M, Gospel, Amy, Chinnery, Patrick F, Samuels, David C, Taylor, Geoffrey A, Plusa, Stefan M, Needham, Stephanie J, Greaves, Laura C, Kirkwood, Thomas B L, Turnbull, Douglass M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging Bats Biomedical research Cancer Colon - cytology Colon - metabolism Cytochrome Dehydrogenases Disease DNA Replication DNA, Mitochondrial - genetics Electron Transport Genomes Humans Mathematics Middle Aged Mitochondria Mitochondrial DNA Models, Genetic Mutation Phosphorylation Proteins Stem cells Stem Cells - metabolism Transfer RNA Tumors
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