Influence of mechanical activation on the physical stability of salbutamol sulphate

In order to obtain the optimal particle size distribution for pharmaceutical powders in dry powder inhalers the particles have to be micronised. In most cases the process of micronisation is connected with a high input of energy which induces disorder and defects on the surface of the drug particles...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2003-11, Vol.56 (3), p.393-400
Hauptverfasser:	Brodka-Pfeiffer, Katharina, Langguth, Peter, Graβ, Peter, Häusler, Heribert
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuterol - chemistry Amorphous Analysis Biological and medical sciences Calorimetry - methods Chemical Phenomena Chemistry, Physical Drug Stability General pharmacology Mechanical activation Medical sciences Micronisation Particle Size Pharmacology. Drug treatments Respiratory system Salbutamol sulphate Stress, Mechanical Technology, Pharmaceutical - instrumentation Technology, Pharmaceutical - methods
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