Chronic pretreatment with candesartan improves recovery from focal cerebral ischaemia in rats

OBJECTIVEIn the present study, we investigated whether systemic pretreatment with the AT1 receptor antagonist, candesartan, reduces neuronal injury after cerebral ischaemia in rats. DESIGN AND METHODSFocal cerebral ischaemia in male, normotensive Wistar rats was induced by 90 min middle cerebral art...

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Veröffentlicht in:	Journal of hypertension 2003-11, Vol.21 (11), p.2175-2182
Hauptverfasser:	Groth, Wolf, Blume, Annegret, Gohlke, Peter, Unger, Thomas, Culman, Juraj
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers Animals Arterial hypertension. Arterial hypotension Benzimidazoles - administration & dosage Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Brain Ischemia - physiopathology Cardiology. Vascular system Cerebral Infarction - pathology Dose-Response Relationship, Drug Drug Administration Schedule Injections, Intravenous Injections, Subcutaneous Male Medical sciences Nervous System - drug effects Nervous System - physiopathology Nervous System Diseases - prevention & control Rats Rats, Wistar Recovery of Function Tetrazoles - administration & dosage
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