Tailoring in Vitro Selection for a Picomolar Affinity Human Antibody Directed against Vascular Endothelial Growth Factor Receptor 2 for Enhanced Neutralizing Activity

Vascular endothelial growth factor (VEGF) and its receptors have been implicated in promoting solid tumor growth and metastasis via stimulating tumor-associated angiogenesis. We previously identified several fully human neutralizing anti-VEGF receptor 2 (or kinase inserting domain-containing recepto...

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Veröffentlicht in:	The Journal of biological chemistry 2003-10, Vol.278 (44), p.43496-43507
Hauptverfasser:	Lu, Dan, Shen, Juqun, Vil, Marie D., Zhang, Haifan, Jimenez, Xenia, Bohlen, Peter, Witte, Larry, Zhu, Zhenping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Angiogenesis Inhibitors - pharmacology Antibodies - chemistry Cell Line, Tumor Cell Movement Dose-Response Relationship, Immunologic Endothelial Cells - metabolism Endothelium, Vascular - cytology Enzyme-Linked Immunosorbent Assay Epitope Mapping Epitopes - chemistry Humans Kinetics Molecular Sequence Data Peptide Library Phosphorylation Protein Binding Protein Structure, Tertiary Sequence Homology, Amino Acid Umbilical Veins - cytology vascular endothelial growth factor 2 Vascular Endothelial Growth Factor Receptor-2 - chemistry Vascular Endothelial Growth Factor Receptor-2 - metabolism
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