Detection of transposon Tn5432–mediated macrolide-lincosamide-streptogramin B (MLSB) resistance in cutaneous propionibacteria from six European cities

Forty-five cutaneous propionibacterial isolates from six European cities were found to be highly resistant to all macrolide-lincosamide-streptogramin B antibiotics, including the ketolide telithromycin. This contrasts with previously documented phenotypes associated with 23S rRNA mutations. Sequenci...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antimicrobial chemotherapy 2002-01, Vol.49 (1), p.165-168
Hauptverfasser:	Ross, Jeremy I., Eady, E. Anne, Carnegie, Ellen, Cove, Jonathan H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acne Vulgaris - drug therapy Acne Vulgaris - genetics Acne Vulgaris - microbiology Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacteriology Biological and medical sciences DNA Transposable Elements - genetics Drug Resistance, Multiple, Bacterial - genetics Europe - epidemiology Fundamental and applied biological sciences. Psychology Genetics Humans Ketolides Lincosamides Macrolides Microbiology Propionibacteriaceae - drug effects Propionibacteriaceae - genetics Propionibacteriaceae - isolation & purification Streptogramin B - pharmacology Streptogramin B - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Forty-five cutaneous propionibacterial isolates from six European cities were found to be highly resistant to all macrolide-lincosamide-streptogramin B antibiotics, including the ketolide telithromycin. This contrasts with previously documented phenotypes associated with 23S rRNA mutations. Sequencing of the resistance determinant showed it to be erm(X) of corynebacterial origin located on the composite transposon Tn5432.
ISSN:	0305-7453 1460-2091 1460-2091
DOI:	10.1093/jac/49.1.165