Effect of Epidural Morphine on Minimum Alveolar Concentration of Isoflurane in Humans

Effect of Epidural Morphine on Minimum Alveolar Concentration of Isoflurane in Humans

BACKGROUND AND AIMS: The anaesthetic potency of volatile anaesthetic agents is measured by the minimum alveolar concentration (MAC) required to suppress response in 50% of subjects. We studied the effect of epidural morphine on MAC of isoflurane in humans. SETTINGS AND DESIGN: A prospective single-b...

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Veröffentlicht in:Journal of postgraduate medicine (Bombay) 2003-07, Vol.49 (3), p.211-213
1. Verfasser: Kashyap L, Pawar DK, Kaul HL, Mohan VK, Dwivedi SN
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Analgesia, Epidural
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - pharmacology
Analysis
Anesthetics
Anesthetics, Inhalation - administration & dosage
Anesthetics, Inhalation - pharmacokinetics
Female
Humans
Influence
Isoflurane
Isoflurane - administration & dosage
Isoflurane - pharmacokinetics
Male
Morphine
Morphine - administration & dosage
Morphine - pharmacology
Peridural anesthesia
Physiological aspects
Preanesthetic Medication
Prospective Studies
Pulmonary Alveoli - metabolism
Statistics
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Zusammenfassung:BACKGROUND AND AIMS: The anaesthetic potency of volatile anaesthetic agents is measured by the minimum alveolar concentration (MAC) required to suppress response in 50% of subjects. We studied the effect of epidural morphine on MAC of isoflurane in humans. SETTINGS AND DESIGN: A prospective single-blind study designed to study the effect of epidural morphine on MAC of isoflurane. SUBJECTS AND METHODS: Forty-eight patients were randomly divided into two groups - Group I patients received 3 mg morphine in 10 ml saline, and Group II patients received 10 ml saline epidurally. Anaesthesia was induced with isoflurane in oxygen and nitrous oxide. Later nitrous oxide was discontinued and MAC of isoflurane determined using modified Dixon's method of sequential sampling. RESULTS: Epidural morphine resulted in a significant reduction in MAC of isoflurane, 0.98 vs. 1.14 in control group (p
ISSN:0022-3859