MITF-M plays an essential role in transcriptional activation and signal transduction in Xiphophorus melanoma

The teleost Xiphophorus provides a genetically well-described model system to study the molecular processes underlying melanoma formation. As transcriptional deregulation is a widespread phenomenon in many tumors, we have studied the regulation of melanoma-specific gene expression in this fish. A ce...

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Veröffentlicht in:	Gene 2003-11, Vol.320, p.117-126
Hauptverfasser:	Delfgaauw, Jacqueline, Duschl, Jutta, Wellbrock, Claudia, Froschauer, Christin, Schartl, Manfred, Altschmied, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Base Sequence Binding Sites - genetics Butadienes - pharmacology Cell Line Cell Line, Tumor Cyprinodontiformes - genetics Cyprinodontiformes - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Electrophoretic Mobility Shift Assay Enzyme Inhibitors - pharmacology Fish Proteins - antagonists & inhibitors Fish Proteins - metabolism Freshwater Humans Luciferases - genetics Luciferases - metabolism MAPkinase Melanoma - genetics Melanoma - metabolism Melanoma - pathology Microphthalmia-Associated Transcription Factor MITF protein Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Monophenol Monooxygenase - genetics Nitriles - pharmacology Nuclear Proteins - metabolism Oryzias - genetics Oryzias latipes Promoter Regions, Genetic - genetics Protein Binding Protein Isoforms - genetics Protein Isoforms - physiology Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal Transduction - drug effects Teleostei Transcription Factors - genetics Transcription Factors - physiology Transcriptional Activation - drug effects Transfection Tyrphostins - pharmacology Xiphophorus Xmrk Xmrk gene
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