Aspirin and the fibrinolytic response
Apart from the anti-inflammatory action, aspirin (ASA) by inhibiting thromboxane A2 synthesis, decreases platelets activity and possesses the antithrombotic action. However, an ASA effect on fibrinolysis has not been yet finally established. Menon [Lancet 1 (1970) 364] reported increased fibrinolyti...
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| Veröffentlicht in: | Thrombosis research 2003-06, Vol.110 (5-6), p.331-334 |
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| container_title | Thrombosis research |
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| creator | Buczko, Włodzimierz Mogielnicki, Andrzej Kramkowski, Karol Chabielska, Ewa |
| description | Apart from the anti-inflammatory action, aspirin (ASA) by inhibiting thromboxane A2 synthesis, decreases platelets activity and possesses the antithrombotic action. However, an ASA effect on fibrinolysis has not been yet finally established. Menon [Lancet 1 (1970) 364] reported increased fibrinolytic response in patients treated with high doses of ASA and this observation started a series of studies to find the relation between aspirin and fibrinolysis. This review comprises the results of those studies, divided into in vitro and in vivo, animal and human experiments. The results of our animal studies are also included. Data survey shows that the ASA effect on fibrinolysis depends on experimental conditions, the dose and the time of drug administration. The results of our study indicate the essential role of plasma components in the fibrinolysis regulation by ASA. |
| doi_str_mv | 10.1016/j.thromres.2003.08.006 |
| format | Article |
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However, an ASA effect on fibrinolysis has not been yet finally established. Menon [Lancet 1 (1970) 364] reported increased fibrinolytic response in patients treated with high doses of ASA and this observation started a series of studies to find the relation between aspirin and fibrinolysis. This review comprises the results of those studies, divided into in vitro and in vivo, animal and human experiments. The results of our animal studies are also included. Data survey shows that the ASA effect on fibrinolysis depends on experimental conditions, the dose and the time of drug administration. 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However, an ASA effect on fibrinolysis has not been yet finally established. Menon [Lancet 1 (1970) 364] reported increased fibrinolytic response in patients treated with high doses of ASA and this observation started a series of studies to find the relation between aspirin and fibrinolysis. This review comprises the results of those studies, divided into in vitro and in vivo, animal and human experiments. The results of our animal studies are also included. Data survey shows that the ASA effect on fibrinolysis depends on experimental conditions, the dose and the time of drug administration. The results of our study indicate the essential role of plasma components in the fibrinolysis regulation by ASA.</description><subject>Animals</subject><subject>ASA</subject><subject>Aspirin</subject><subject>Aspirin - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endothelial Cells - drug effects</subject><subject>Endothelial Cells - physiology</subject><subject>Fibrinolysis - drug effects</subject><subject>Fibrinolysis - physiology</subject><subject>Fibrinolytic Agents - pharmacology</subject><subject>Fibrinolytic response</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet Activation - drug effects</subject><subject>Platelet Activation - physiology</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWqt_QXqpt10nX5vkpohfUPCi55DNztKU7W5NtoL_3pRWevQ0DDzvO8NDyA2FkgKt7lbluIzDOmIqGQAvQZcA1QmZUK1MwYRip2QCIEzBtdAX5DKlFQBV1MhzckGFNExKNSHzh7QJMfQz1zezcYmzNtR5HbqfMfhZrt8MfcIrcta6LuH1YU7J5_PTx-NrsXh_eXt8WBSeGzEWHpvWSMcYU7XS2oExFRruJUNNqahoKzmtNVQNyxOUbhshUEjX0IrpWvEpud33buLwtcU02nVIHrvO9Thsk1WUc6EMZLDagz4OKUVs7SaGtYs_loLdCbIr-yfI7gRZ0DYLysGbw4VtvcbmGDsYycD8ALjkXddG1_uQjpzkoCTXmbvfc5h9fAeMNvmAfVYQIvrRNkP475dfcLyF6g</recordid><startdate>20030615</startdate><enddate>20030615</enddate><creator>Buczko, Włodzimierz</creator><creator>Mogielnicki, Andrzej</creator><creator>Kramkowski, Karol</creator><creator>Chabielska, Ewa</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030615</creationdate><title>Aspirin and the fibrinolytic response</title><author>Buczko, Włodzimierz ; Mogielnicki, Andrzej ; Kramkowski, Karol ; Chabielska, Ewa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-cedf95a2227b788a0996e93c52e811461f531b806d231b078fd44e45ad1628b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>ASA</topic><topic>Aspirin</topic><topic>Aspirin - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endothelial Cells - drug effects</topic><topic>Endothelial Cells - physiology</topic><topic>Fibrinolysis - drug effects</topic><topic>Fibrinolysis - physiology</topic><topic>Fibrinolytic Agents - pharmacology</topic><topic>Fibrinolytic response</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet Activation - drug effects</topic><topic>Platelet Activation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buczko, Włodzimierz</creatorcontrib><creatorcontrib>Mogielnicki, Andrzej</creatorcontrib><creatorcontrib>Kramkowski, Karol</creatorcontrib><creatorcontrib>Chabielska, Ewa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buczko, Włodzimierz</au><au>Mogielnicki, Andrzej</au><au>Kramkowski, Karol</au><au>Chabielska, Ewa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aspirin and the fibrinolytic response</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2003-06-15</date><risdate>2003</risdate><volume>110</volume><issue>5-6</issue><spage>331</spage><epage>334</epage><pages>331-334</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>Apart from the anti-inflammatory action, aspirin (ASA) by inhibiting thromboxane A2 synthesis, decreases platelets activity and possesses the antithrombotic action. However, an ASA effect on fibrinolysis has not been yet finally established. Menon [Lancet 1 (1970) 364] reported increased fibrinolytic response in patients treated with high doses of ASA and this observation started a series of studies to find the relation between aspirin and fibrinolysis. This review comprises the results of those studies, divided into in vitro and in vivo, animal and human experiments. The results of our animal studies are also included. Data survey shows that the ASA effect on fibrinolysis depends on experimental conditions, the dose and the time of drug administration. The results of our study indicate the essential role of plasma components in the fibrinolysis regulation by ASA.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>14592557</pmid><doi>10.1016/j.thromres.2003.08.006</doi><tpages>4</tpages></addata></record> |
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| ispartof | Thrombosis research, 2003-06, Vol.110 (5-6), p.331-334 |
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| subjects | Animals ASA Aspirin Aspirin - administration & dosage Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - physiology Fibrinolysis - drug effects Fibrinolysis - physiology Fibrinolytic Agents - pharmacology Fibrinolytic response Humans Medical sciences Pharmacology. Drug treatments Platelet Activation - drug effects Platelet Activation - physiology |
| title | Aspirin and the fibrinolytic response |
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