In vitro testing of the leukaemia monoclonal antibody WM-53 labeled with alpha and beta emitting radioisotopes

We report the preparation and testing of a new alpha emitting radio-immunoconjugate (RIC) against acute myeloid leukaemia (AML) using CD33 positive monoclonal antibody WM-53 (specific for HL-60 cell line). Using cyclic anhydride of diethylenetriaminepentacetic acid (cDTPAa) as chelator, antibody was...

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Veröffentlicht in:	Leukemia research 2002, Vol.26 (1), p.37-43
Hauptverfasser:	Abbas Rizvi, Syed M., Henniker, A.J., Goozee, G., Allen, B.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute myeloid leukaemia Alpha Particles - therapeutic use Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - therapeutic use Antigens, CD - immunology Antigens, Differentiation, Myelomonocytic - immunology Beta Particles - therapeutic use Biological and medical sciences Bismuth-213 Cell Survival - radiation effects Chelating Agents - chemistry Cytotoxicity DNA Replication - radiation effects DNA synthesis DNA, Neoplasm - radiation effects Flow Cytometry Hemopathies HL-60 Cells - radiation effects Humans Immunoconjugates - chemistry Immunoconjugates - therapeutic use In Vitro Techniques Isotope Labeling Labeling efficiency Leukemia, Myeloid - genetics Leukemia, Myeloid - radiotherapy Medical sciences Monoclonal antibodies Pentetic Acid - chemistry Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Sialic Acid Binding Ig-like Lectin 3 Targeted alpha therapy
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