Enalapril increases mitochondrial nitric oxide synthase activity in heart and liver

Heart and liver mitochondria isolated from rats treated with enalapril, 3-30 mg/kg/day in the drinking water for 7-120 days, showed a time- and dose-dependent increased nitric oxide (NO) production in the range of 14-250%. Heart and liver mitochondria from control rats produced 0.69 and 0.50 nmol of...

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Veröffentlicht in:	Antioxidants & redox signaling 2003-12, Vol.5 (6), p.691-697
Hauptverfasser:	Boveris, Alberto, D'Amico, Gabriela, Lores-Arnaiz, Silvia, Costa, Lidia E
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Dose-Response Relationship, Drug Enalapril - pharmacology Hemoglobins - metabolism Hydrogen Peroxide - pharmacology Liver - metabolism Male Methemoglobin - metabolism Mitochondria - metabolism Models, Biological Myocardium - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Oxidation-Reduction Oxygen - metabolism Rats Rats, Wistar Signal Transduction Spectrophotometry Superoxide Dismutase - metabolism Time Factors Up-Regulation Water - metabolism
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