A Modular Approach to Oxoindolizino Quinolines: Efficient Synthesis of Mappicine Ketone (Nothapodytine B)
A general route to oxoindolizino quinolines, such as nothapodytine A, mappicine, camptothecin, and several chemotherapeutic derivatives, is illustrated by the synthesis of the antiviral natural product from Nothapodytes foetida, mappicine ketone (R1=R4=H, R2=CH3, R3=COC2H5). A wide range of new camp...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2003-10, Vol.42 (41), p.5059-5061 |
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| container_issue | 41 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Raolji, Gajendra B. Garçon, Stéphanie Greene, Andrew E. Kanazawa, Alice |
| description | A general route to oxoindolizino quinolines, such as nothapodytine A, mappicine, camptothecin, and several chemotherapeutic derivatives, is illustrated by the synthesis of the antiviral natural product from Nothapodytes foetida, mappicine ketone (R1=R4=H, R2=CH3, R3=COC2H5). A wide range of new camptothecinoids should now be readily available for biological testing. |
| doi_str_mv | 10.1002/anie.200352094 |
| format | Article |
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| subjects | Combinatorial Chemistry Techniques - methods cross-coupling cycloaddition Indolizines - chemical synthesis isomerization Models, Chemical Molecular Structure Quinolines - chemical synthesis rearrangement total synthesis |
| title | A Modular Approach to Oxoindolizino Quinolines: Efficient Synthesis of Mappicine Ketone (Nothapodytine B) |
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