Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone

IL-6 has emerged as an important cytokine upregulated in states of insulin resistance such as type 2 diabetes. We evaluated the chronic effect of IL-6 on insulin signaling in 3T3-F442A and 3T3-L1 adipocytes. First, cells responded to a chronic treatment with IL-6 by initiating an autoactivation proc...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-11, Vol.311 (2), p.372-379
Hauptverfasser:	Lagathu, Claire, Bastard, Jean-Philippe, Auclair, Martine, Maachi, Mustapha, Capeau, Jacqueline, Caron, Martine
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells 3T3-L1 Cells Adipocyte Adipocytes - drug effects Adipocytes - metabolism Animals Cytokine Dose-Response Relationship, Drug Glucose - metabolism Insulin resistance Insulin Resistance - physiology Interleukin-6 Interleukin-6 - metabolism Interleukin-6 - pharmacology Mice Proteins - metabolism Repressor Proteins Rosiglitazone Signal Transduction - drug effects Signal Transduction - physiology Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Thiazolidinedione Thiazolidinediones - pharmacology Transcription Factors Up-Regulation - drug effects Up-Regulation - physiology
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