IgM and IgG autoantibodies from microscopic polyangiitis patients but not those with other small- and medium-sized vessel vasculitides recognize multiple endothelial cell antigens

Using a quantitative immunoblotting technique on extracts of macrovascular and microvascular endothelial cells (EC), we analyzed serum IgM and IgG reactivities of patients with active disease fulfilling the ACR and Chapel Hill criteria for the diagnosis of polyarteritis nodosa (PAN) ( n = 8), PAN re...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2003-11, Vol.109 (2), p.165-178
Hauptverfasser:	Chanseaud, Youri, Peña-Lefebvre, Paloma García de la, Guilpain, Philippe, Mahr, Alfred, Tamby, Mathieu C, Uzan, Michèle, Guillevin, Loïc, Boissier, Marie-Christophe, Mouthon, Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoantibodies - immunology Autoantibody Biological and medical sciences Blotting, Western Churg-Strauss Syndrome - immunology Endothelial cell Endothelium, Vascular - immunology Female Fluorescent Antibody Technique, Indirect General aspects Granulomatosis with Polyangiitis - immunology Hepatitis B virus Humans Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M - blood Immunoglobulin M - immunology Immunopathology Male Medical sciences Microscopic polyangiitis Middle Aged Polyarteritis Nodosa - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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