Reduction in distractibility with AF102B and THA in the macaque
Distractibility in primates may be influenced by central cholinergic systems. Two cholinomimetics, the m-1 muscarinic agonist (±)- cis-2-methyl-spiro(1,3-oxathiolane-5,3′)quinuclidine (AF102B, civemeline) and the cholinesterase inhibitor tetrahydroaminoacridine (THA, tacrine), were compared to vehic...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2003-09, Vol.76 (2), p.301-306 |
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| creator | O'Neill, Joseph Siembieda, Douglas W. Crawford, K.Casey Halgren, Eric Fisher, Abraham Fitten, L.Jaime |
| description | Distractibility in primates may be influenced by central cholinergic systems. Two cholinomimetics, the m-1 muscarinic agonist (±)-
cis-2-methyl-spiro(1,3-oxathiolane-5,3′)quinuclidine (AF102B, civemeline) and the cholinesterase inhibitor tetrahydroaminoacridine (THA, tacrine), were compared to vehicle controls for effects on distractibility in an automated visuospatial attention task. The task required visual pursuit of a moving target amongst distractor stimuli that acted to impair performance and was executed by seven healthy adult bonnet macaque monkeys. Task accuracy and reaction time were measured 1.5 h after systemic administration of each substance. For the seven-subject group at individually titrated best doses, accuracy increased significantly relative to vehicle for both drugs. Reaction time at best dose decreased for both drugs, but not significantly. Muscarinic agonists and cholinesterase inhibitors may reduce distractibility in primates. |
| doi_str_mv | 10.1016/j.pbb.2003.08.006 |
| format | Article |
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cis-2-methyl-spiro(1,3-oxathiolane-5,3′)quinuclidine (AF102B, civemeline) and the cholinesterase inhibitor tetrahydroaminoacridine (THA, tacrine), were compared to vehicle controls for effects on distractibility in an automated visuospatial attention task. The task required visual pursuit of a moving target amongst distractor stimuli that acted to impair performance and was executed by seven healthy adult bonnet macaque monkeys. Task accuracy and reaction time were measured 1.5 h after systemic administration of each substance. For the seven-subject group at individually titrated best doses, accuracy increased significantly relative to vehicle for both drugs. Reaction time at best dose decreased for both drugs, but not significantly. Muscarinic agonists and cholinesterase inhibitors may reduce distractibility in primates.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/j.pbb.2003.08.006</identifier><identifier>PMID: 14592682</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>AF102B ; Animals ; Attention - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Cholinergic system ; Cholinesterase inhibitors ; Cholinesterase Inhibitors - pharmacology ; Conditioning, Operant - drug effects ; Distractibility ; Female ; Fundamental and applied biological sciences. Psychology ; Macaca radiata ; Male ; Medical sciences ; Monkeys ; Muscarinic agonists ; Muscarinic Agonists - pharmacology ; Neuropharmacology ; Neurotransmission and behavior ; Neurotransmitters. Neurotransmission. Receptors ; Nootropic Agents - pharmacology ; Pharmacology. Drug treatments ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychomotor Performance - drug effects ; Quinuclidines - pharmacology ; Space Perception - drug effects ; Tacrine - pharmacology ; THA ; Thiophenes ; Visual Perception - drug effects</subject><ispartof>Pharmacology, biochemistry and behavior, 2003-09, Vol.76 (2), p.301-306</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-5f1d734cc54ede75887a29b6796099b9e5488c94c5d9ee1c114c8564d2070a6c3</citedby><cites>FETCH-LOGICAL-c410t-5f1d734cc54ede75887a29b6796099b9e5488c94c5d9ee1c114c8564d2070a6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pbb.2003.08.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15280730$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14592682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Neill, Joseph</creatorcontrib><creatorcontrib>Siembieda, Douglas W.</creatorcontrib><creatorcontrib>Crawford, K.Casey</creatorcontrib><creatorcontrib>Halgren, Eric</creatorcontrib><creatorcontrib>Fisher, Abraham</creatorcontrib><creatorcontrib>Fitten, L.Jaime</creatorcontrib><title>Reduction in distractibility with AF102B and THA in the macaque</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Distractibility in primates may be influenced by central cholinergic systems. Two cholinomimetics, the m-1 muscarinic agonist (±)-
cis-2-methyl-spiro(1,3-oxathiolane-5,3′)quinuclidine (AF102B, civemeline) and the cholinesterase inhibitor tetrahydroaminoacridine (THA, tacrine), were compared to vehicle controls for effects on distractibility in an automated visuospatial attention task. The task required visual pursuit of a moving target amongst distractor stimuli that acted to impair performance and was executed by seven healthy adult bonnet macaque monkeys. Task accuracy and reaction time were measured 1.5 h after systemic administration of each substance. For the seven-subject group at individually titrated best doses, accuracy increased significantly relative to vehicle for both drugs. Reaction time at best dose decreased for both drugs, but not significantly. Muscarinic agonists and cholinesterase inhibitors may reduce distractibility in primates.</description><subject>AF102B</subject><subject>Animals</subject><subject>Attention - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cholinergic system</subject><subject>Cholinesterase inhibitors</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Conditioning, Operant - drug effects</subject><subject>Distractibility</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Macaca radiata</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monkeys</subject><subject>Muscarinic agonists</subject><subject>Muscarinic Agonists - pharmacology</subject><subject>Neuropharmacology</subject><subject>Neurotransmission and behavior</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Nootropic Agents - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychomotor Performance - drug effects</subject><subject>Quinuclidines - pharmacology</subject><subject>Space Perception - drug effects</subject><subject>Tacrine - pharmacology</subject><subject>THA</subject><subject>Thiophenes</subject><subject>Visual Perception - drug effects</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFEEQhhtRzBr9AV5kLnqbsaqnP_EgazBGCAgSz01Pdy3pZXZm7Z6N5N_byy7kpqei4HnfKh7G3iJ0CKg-brv9MHQcoO_AdADqGVuh0X0rUevnbAVgse1B6gv2qpQtAAiu9Et2gUJargxfsc8_KR7CkuapSVMTU1myr-uQxrQ8Nn_Sct-srxH4l8ZPsbm7WR-x5Z6anQ_-94FesxcbPxZ6c56X7Nf117urm_b2x7fvV-vbNgiEpZUbjLoXIUhBkbQ0RntuB6WtAmsHS1IYE6wIMloiDIgiGKlE5KDBq9Bfsg-n3n2e69myuF0qgcbRTzQfitPYc4tC_xdEU28LZSqIJzDkuZRMG7fPaefzo0NwR71u66ped9TrwLiqt2bencsPw47iU-LsswLvz4AvwY-b7KeQyhMnuQHdQ-U-nTiqzh4SZVdCoilQTJnC4uKc_vHGX7jvlJE</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>O'Neill, Joseph</creator><creator>Siembieda, Douglas W.</creator><creator>Crawford, K.Casey</creator><creator>Halgren, Eric</creator><creator>Fisher, Abraham</creator><creator>Fitten, L.Jaime</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Reduction in distractibility with AF102B and THA in the macaque</title><author>O'Neill, Joseph ; Siembieda, Douglas W. ; Crawford, K.Casey ; Halgren, Eric ; Fisher, Abraham ; Fitten, L.Jaime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-5f1d734cc54ede75887a29b6796099b9e5488c94c5d9ee1c114c8564d2070a6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>AF102B</topic><topic>Animals</topic><topic>Attention - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cholinergic system</topic><topic>Cholinesterase inhibitors</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Conditioning, Operant - drug effects</topic><topic>Distractibility</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Macaca radiata</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monkeys</topic><topic>Muscarinic agonists</topic><topic>Muscarinic Agonists - pharmacology</topic><topic>Neuropharmacology</topic><topic>Neurotransmission and behavior</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Nootropic Agents - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychomotor Performance - drug effects</topic><topic>Quinuclidines - pharmacology</topic><topic>Space Perception - drug effects</topic><topic>Tacrine - pharmacology</topic><topic>THA</topic><topic>Thiophenes</topic><topic>Visual Perception - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Neill, Joseph</creatorcontrib><creatorcontrib>Siembieda, Douglas W.</creatorcontrib><creatorcontrib>Crawford, K.Casey</creatorcontrib><creatorcontrib>Halgren, Eric</creatorcontrib><creatorcontrib>Fisher, Abraham</creatorcontrib><creatorcontrib>Fitten, L.Jaime</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Neill, Joseph</au><au>Siembieda, Douglas W.</au><au>Crawford, K.Casey</au><au>Halgren, Eric</au><au>Fisher, Abraham</au><au>Fitten, L.Jaime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction in distractibility with AF102B and THA in the macaque</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>76</volume><issue>2</issue><spage>301</spage><epage>306</epage><pages>301-306</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Distractibility in primates may be influenced by central cholinergic systems. Two cholinomimetics, the m-1 muscarinic agonist (±)-
cis-2-methyl-spiro(1,3-oxathiolane-5,3′)quinuclidine (AF102B, civemeline) and the cholinesterase inhibitor tetrahydroaminoacridine (THA, tacrine), were compared to vehicle controls for effects on distractibility in an automated visuospatial attention task. The task required visual pursuit of a moving target amongst distractor stimuli that acted to impair performance and was executed by seven healthy adult bonnet macaque monkeys. Task accuracy and reaction time were measured 1.5 h after systemic administration of each substance. For the seven-subject group at individually titrated best doses, accuracy increased significantly relative to vehicle for both drugs. Reaction time at best dose decreased for both drugs, but not significantly. Muscarinic agonists and cholinesterase inhibitors may reduce distractibility in primates.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14592682</pmid><doi>10.1016/j.pbb.2003.08.006</doi><tpages>6</tpages></addata></record> |
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| subjects | AF102B Animals Attention - drug effects Behavioral psychophysiology Biological and medical sciences Cholinergic system Cholinesterase inhibitors Cholinesterase Inhibitors - pharmacology Conditioning, Operant - drug effects Distractibility Female Fundamental and applied biological sciences. Psychology Macaca radiata Male Medical sciences Monkeys Muscarinic agonists Muscarinic Agonists - pharmacology Neuropharmacology Neurotransmission and behavior Neurotransmitters. Neurotransmission. Receptors Nootropic Agents - pharmacology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - drug effects Quinuclidines - pharmacology Space Perception - drug effects Tacrine - pharmacology THA Thiophenes Visual Perception - drug effects |
| title | Reduction in distractibility with AF102B and THA in the macaque |
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