Hypertonicity promotes survival of corticospinal motoneurons via mitogen-activated protein kinase p38 signaling

Extracellular hypertonicity can induce the phosphorylation of mitogen-activated protein kinases (MAPKs). Of these, both extracellular signal-regulated kinases (ERKs) and the stress-activated kinase p38 have been implicated in neuronal cell survival. Resuscitation with hypertonic saline decreases sec...

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Veröffentlicht in:	Journal of molecular neuroscience 2003-01, Vol.21 (2), p.111-120
Hauptverfasser:	Junger, Heidi, Edelman, David B, Junger, Wolfgang G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Cell Death - drug effects Cell Death - physiology Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Choline - pharmacology Culture Media, Serum-Free - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Hypertonic Solutions - pharmacology Hypertonic Solutions - therapeutic use Kinases MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism Motor Neurons - drug effects Motor Neurons - enzymology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use p38 Mitogen-Activated Protein Kinases Phosphorylation Phosphorylation - drug effects Potassium Chloride - pharmacology Proteins Pyramidal Cells - drug effects Pyramidal Cells - enzymology Pyramidal Tracts - drug effects Pyramidal Tracts - enzymology Rats Rats, Sprague-Dawley Sodium Chloride - pharmacology Sucrose - pharmacology
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