Genome scans and candidate gene approaches in the study of common diseases and variable drug responses

There is both tremendous enthusiasm and controversy surrounding genetic association studies. In this article we use new methods for representing variation in the human genome that suggest as a few as 170 000 carefully selected single nucleotide polymorphisms (SNPs) are sufficient to represent all th...

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Veröffentlicht in:	Trends in genetics 2003-11, Vol.19 (11), p.615-622
Hauptverfasser:	Goldstein, David B., Ahmadi, Kourosh R., Weale, Mike E., Wood, Nicholas W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Humans Linkage Disequilibrium Molecular and cellular biology Pharmacology, Clinical Polymorphism, Single Nucleotide Sequence Tagged Sites
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