Tissue storage of 14C-labelled hydroxyethyl starch (HES) 130/0.4 and HES 200/0.5 after repeated intravenous administration to rats

To investigate the effect of the molar substitution of hydroxyethyl starch (HES) solutions on tissue and organ storage in rats after repeated administration. A controlled, multiple-dose study was performed in 48 rats. Daily bolus injections of 0.7 g/kg of 10% HES 130/0.4 or 10% HES 200/0.5 were admi...

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Veröffentlicht in:	Drugs in R&D 2003, Vol.4 (6), p.331-338
Hauptverfasser:	Leuschner, Jost, Opitz, Jens, Winkler, Andreas, Scharpf, Roland, Bepperling, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Radioisotopes Female Hydroxyethyl Starch Derivatives - administration & dosage Hydroxyethyl Starch Derivatives - chemistry Hydroxyethyl Starch Derivatives - pharmacokinetics Injections, Intravenous Molecular Weight Plasma Substitutes - administration & dosage Plasma Substitutes - chemistry Plasma Substitutes - pharmacokinetics Rats Rats, Sprague-Dawley Tissue Distribution
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