Reversible “Irreversible” Inhibition of Chymotrypsin Using Nanoparticle Receptors

Anionically functionalized amphiphilic nanoparticles efficiently inhibit chymotrypsin through electrostatic binding followed by protein denaturation. We demonstrate the ability to disrupt this “irreversible” inhibition of chymotrypsin through modification of the nanoparticle surface using cationic s...

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Veröffentlicht in:	Journal of the American Chemical Society 2003-11, Vol.125 (44), p.13387-13391
Hauptverfasser:	Fischer, Nicholas O, Verma, Ayush, Goodman, Catherine M, Simard, Joseph M, Rotello, Vincent M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carboxylic Acids - chemistry Chymotrypsin - antagonists & inhibitors Fluorescence Polarization Fundamental and applied biological sciences. Psychology Gold - chemistry Interactions. Associations Intermolecular phenomena Molecular biophysics Nanotechnology Particle Size Protein Denaturation Static Electricity Surface Properties Surface-Active Agents - chemistry
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