A new access to polyhydroxy piperidines of the azasugar class: synthesis and glycosidase inhibition studies

A new synthetic strategy has been devised to access a variety of polyhydroxylated piperidines belonging to the azasugar class of glycosidase inhibitors. The key precursor (3aR, 7aR)-5-benzyl-2,2-dimethyl-7-methylenehexahydro[1,3]dioxo[4,5-c]pyridine is obtained by photoinduced electron transfer (PET...

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Veröffentlicht in:	Organic & biomolecular chemistry 2003-10, Vol.1 (19), p.3321-3326
Hauptverfasser:	Pandey, Ganesh, Kapur, Manmohan, Khan, M Islam, Gaikwad, Sushama M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aza Compounds - chemical synthesis Aza Compounds - chemistry Aza Compounds - pharmacology Glycoside Hydrolases - antagonists & inhibitors Glycoside Hydrolases - metabolism Hydroxylation Imino Pyranoses Molecular Structure Piperidines - chemical synthesis Piperidines - chemistry Piperidines - pharmacology Stereoisomerism
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