Pharmacologic pre-conditioning and controlled reperfusion prevent ischemia–reperfusion injury after 30 minutes of hypoxia/ischemia in porcine hearts

Hearts from non–heart-beating organ donors are not transplanted because of risk of ischemia-reperfusion injury. We tested whether pharmacologic pre-conditioning with adenosine and the Na +/H + exchanger inhibitor, cariporide, combined with controlled reperfusion, would prevent injury in porcine hear...

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Veröffentlicht in:	The Journal of heart and lung transplantation 2003-11, Vol.22 (11), p.1234-1244
Hauptverfasser:	Fedalen, P.A, Piacentino, V, Jeevanandam, V, Fisher, C, Greene, J, Margulies, K.B, Houser, S.R, Furukawa, S, Singhal, A.K, Goldman, B.I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - therapeutic use Animals Anti-Arrhythmia Agents - therapeutic use Biological and medical sciences Creatine Kinase - metabolism Guanidines - therapeutic use Heart - drug effects Heart - physiopathology Hypoxia - metabolism Ischemic Preconditioning, Myocardial - methods Medical sciences Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Myocardium - enzymology Myocardium - pathology Sulfones - therapeutic use Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Swine Vasodilator Agents - therapeutic use
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