Interleukin-6 promoter −174 polymorphism and spontaneous preterm birth
We assessed the relationship between interleukin-6 (IL-6) promoter −174 polymorphism and spontaneous preterm birth (sPTB) less than 34 weeks and the relationship of polymorphism status with race. Polymerase chain reaction was used to evaluate DNA from 156 controls who delivered after spontaneous lab...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2003-10, Vol.189 (4), p.915-918 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Simhan, Hyagriv N Krohn, Marijane A Roberts, James M Zeevi, Adriana Caritis, Steve N |
| description | We assessed the relationship between interleukin-6 (IL-6) promoter −174 polymorphism and spontaneous preterm birth (sPTB) less than 34 weeks and the relationship of polymorphism status with race.
Polymerase chain reaction was used to evaluate DNA from 156 controls who delivered after spontaneous labor at term and 51 subjects who had sPTB less than 34 weeks.
Among the 156 controls, the C/C variant was present in 30 (19.2%). Among the 51 subjects, the C/C variant was present in 2 (6.3%) (odds ratio 0.17, 95% CI 0.04-0.74). Among white women, the C/C variant was present in 30 (27.2%) controls but only 2 (5.2%) cases. No African American women carried the C/C variant. The racial disparity was statistically significant. (
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| doi_str_mv | 10.1067/S0002-9378(03)00843-3 |
| format | Article |
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Polymerase chain reaction was used to evaluate DNA from 156 controls who delivered after spontaneous labor at term and 51 subjects who had sPTB less than 34 weeks.
Among the 156 controls, the C/C variant was present in 30 (19.2%). Among the 51 subjects, the C/C variant was present in 2 (6.3%) (odds ratio 0.17, 95% CI 0.04-0.74). Among white women, the C/C variant was present in 30 (27.2%) controls but only 2 (5.2%) cases. No African American women carried the C/C variant. The racial disparity was statistically significant. (
P<.001)
The IL-6 promoter −174 allelic variant C/C is significantly less frequent among women with sPTB less than 34 weeks. There is a dramatic racial disparity in the distribution of allelic variants of this polymorphism.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1067/S0002-9378(03)00843-3</identifier><identifier>PMID: 14586325</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Biological and medical sciences ; Black or African American ; Black People - genetics ; cytokine promoter polymorphism ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Interleukin-6 ; Interleukin-6 - genetics ; Medical sciences ; Obstetric Labor, Premature - genetics ; Polymorphism, Genetic ; Pregnancy ; Pregnancy. Fetus. Placenta ; preterm birth ; Promoter Regions, Genetic - genetics ; White People - genetics</subject><ispartof>American journal of obstetrics and gynecology, 2003-10, Vol.189 (4), p.915-918</ispartof><rights>2003 Mosby, Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-e155b39000b6b0139498ad30e208348467f5422ab3a3044a1bbdd29c56fdd4463</citedby><cites>FETCH-LOGICAL-c391t-e155b39000b6b0139498ad30e208348467f5422ab3a3044a1bbdd29c56fdd4463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1067/S0002-9378(03)00843-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,778,782,787,788,3539,23913,23914,25123,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15265848$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14586325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simhan, Hyagriv N</creatorcontrib><creatorcontrib>Krohn, Marijane A</creatorcontrib><creatorcontrib>Roberts, James M</creatorcontrib><creatorcontrib>Zeevi, Adriana</creatorcontrib><creatorcontrib>Caritis, Steve N</creatorcontrib><title>Interleukin-6 promoter −174 polymorphism and spontaneous preterm birth</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>We assessed the relationship between interleukin-6 (IL-6) promoter −174 polymorphism and spontaneous preterm birth (sPTB) less than 34 weeks and the relationship of polymorphism status with race.
Polymerase chain reaction was used to evaluate DNA from 156 controls who delivered after spontaneous labor at term and 51 subjects who had sPTB less than 34 weeks.
Among the 156 controls, the C/C variant was present in 30 (19.2%). Among the 51 subjects, the C/C variant was present in 2 (6.3%) (odds ratio 0.17, 95% CI 0.04-0.74). Among white women, the C/C variant was present in 30 (27.2%) controls but only 2 (5.2%) cases. No African American women carried the C/C variant. The racial disparity was statistically significant. (
P<.001)
The IL-6 promoter −174 allelic variant C/C is significantly less frequent among women with sPTB less than 34 weeks. There is a dramatic racial disparity in the distribution of allelic variants of this polymorphism.</description><subject>Biological and medical sciences</subject><subject>Black or African American</subject><subject>Black People - genetics</subject><subject>cytokine promoter polymorphism</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Interleukin-6</subject><subject>Interleukin-6 - genetics</subject><subject>Medical sciences</subject><subject>Obstetric Labor, Premature - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>preterm birth</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>White People - genetics</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1KAzEQx4MoWquPoOxF0cNqvjc5iRS1BcGDeg7ZJIvR_TLZCn0Dzz6iT2Jqiz16Gmb4zcyfHwBHCF4gyIvLRwghziUpxBkk5xAKSnKyBUYIyiLngottMPpD9sB-jK_LFku8C_YQZYITzEZgOmsHF2o3f_NtzrM-dE2XBtn35xcqaNZ39aLpQv_iY5Pp1max79pBt66bxwS7hDZZ6cPwcgB2Kl1Hd7iuY_B8e_M0meb3D3ezyfV9bohEQ-4QYyWRKUrJS4iIpFJoS6DDUBAqKC8qRjHWJdEEUqpRWVqLpWG8spZSTsbgdHU3RX2fuzioxkfj6noVShWIIAnlEmQr0IQuxuAq1Qff6LBQCKqlQvWrUC39KEjUr0JF0t7x-sG8bJzdbK2dJeBkDehodF0F3RofNxzDnAkqEne14lzS8eFdUNF41xpnfXBmULbz_0T5AZX_jV0</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Simhan, Hyagriv N</creator><creator>Krohn, Marijane A</creator><creator>Roberts, James M</creator><creator>Zeevi, Adriana</creator><creator>Caritis, Steve N</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Interleukin-6 promoter −174 polymorphism and spontaneous preterm birth</title><author>Simhan, Hyagriv N ; Krohn, Marijane A ; Roberts, James M ; Zeevi, Adriana ; Caritis, Steve N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-e155b39000b6b0139498ad30e208348467f5422ab3a3044a1bbdd29c56fdd4463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Black or African American</topic><topic>Black People - genetics</topic><topic>cytokine promoter polymorphism</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Interleukin-6</topic><topic>Interleukin-6 - genetics</topic><topic>Medical sciences</topic><topic>Obstetric Labor, Premature - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>preterm birth</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>White People - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simhan, Hyagriv N</creatorcontrib><creatorcontrib>Krohn, Marijane A</creatorcontrib><creatorcontrib>Roberts, James M</creatorcontrib><creatorcontrib>Zeevi, Adriana</creatorcontrib><creatorcontrib>Caritis, Steve N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simhan, Hyagriv N</au><au>Krohn, Marijane A</au><au>Roberts, James M</au><au>Zeevi, Adriana</au><au>Caritis, Steve N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-6 promoter −174 polymorphism and spontaneous preterm birth</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>189</volume><issue>4</issue><spage>915</spage><epage>918</epage><pages>915-918</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>We assessed the relationship between interleukin-6 (IL-6) promoter −174 polymorphism and spontaneous preterm birth (sPTB) less than 34 weeks and the relationship of polymorphism status with race.
Polymerase chain reaction was used to evaluate DNA from 156 controls who delivered after spontaneous labor at term and 51 subjects who had sPTB less than 34 weeks.
Among the 156 controls, the C/C variant was present in 30 (19.2%). Among the 51 subjects, the C/C variant was present in 2 (6.3%) (odds ratio 0.17, 95% CI 0.04-0.74). Among white women, the C/C variant was present in 30 (27.2%) controls but only 2 (5.2%) cases. No African American women carried the C/C variant. The racial disparity was statistically significant. (
P<.001)
The IL-6 promoter −174 allelic variant C/C is significantly less frequent among women with sPTB less than 34 weeks. There is a dramatic racial disparity in the distribution of allelic variants of this polymorphism.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>14586325</pmid><doi>10.1067/S0002-9378(03)00843-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 2003-10, Vol.189 (4), p.915-918 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Black or African American Black People - genetics cytokine promoter polymorphism Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Interleukin-6 Interleukin-6 - genetics Medical sciences Obstetric Labor, Premature - genetics Polymorphism, Genetic Pregnancy Pregnancy. Fetus. Placenta preterm birth Promoter Regions, Genetic - genetics White People - genetics |
| title | Interleukin-6 promoter −174 polymorphism and spontaneous preterm birth |
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