Inhibition of Invasion and Angiogenesis by Zinc-Chelating Agent Disulfiram

Cell invasion and angiogenesis are crucial processes in cancer metastasis that require extracellular matrix (ECM) degradation. Proteolytic degradation of the ECM components is a central event of invasion and angiogenesis processes. During these processes, matrix metalloproteinases (MMPs) seem to be...

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Veröffentlicht in:	Molecular pharmacology 2003-11, Vol.64 (5), p.1076-1084
Hauptverfasser:	Shian, Shine-Gwo, Kao, Yu-Rung, Wu, Felicia Ying-Hsiueh, Wu, Cheng-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chelating Agents - pharmacology Chickens Disulfiram - pharmacology Humans Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors Neovascularization, Pathologic - physiopathology Tumor Cells, Cultured
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