Plasma C-reactive protein levels in severe diabetic ketoacidosis
Elevated plasma levels of C-reactive protein (CRP) and IL-6 have been reported to be sensitive indicators of infection in adults with diabetic ketoacidosis (DKA). However, both CRP and the pro-inflammatory cytokines, which regulate CRP, can be elevated without infection. Our hypothesis was that CRP...
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| Veröffentlicht in: | Annals of clinical and laboratory science 2003-09, Vol.33 (4), p.435-442 |
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| creator | DALTON, Rory R HOFFMAN, William H PASSMORE, Gregory G MARTIN, S. Lee |
| description | Elevated plasma levels of C-reactive protein (CRP) and IL-6 have been reported to be sensitive indicators of infection in adults with diabetic ketoacidosis (DKA). However, both CRP and the pro-inflammatory cytokines, which regulate CRP, can be elevated without infection. Our hypothesis was that CRP is increased in young patients with severe DKA, even in the absence of an infection, and may serve as a marker for systemic inflammatory response syndrome (SIRS). In 7 patients with severe DKA without infection, we measured plasma CRP, IL-6, IL-1beta and TNF-alpha levels prior to, during, and following correction of DKA. CRP was significantly but transiently elevated in 4 of the patients prior to or during treatment of DKA, compared to their baseline values (96 hr after correction of DKA). There were significant positive relationships between CRP and both IL-6 and IL-1beta prior to treatment (p |
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Lee</creator><creatorcontrib>DALTON, Rory R ; HOFFMAN, William H ; PASSMORE, Gregory G ; MARTIN, S. Lee</creatorcontrib><description>Elevated plasma levels of C-reactive protein (CRP) and IL-6 have been reported to be sensitive indicators of infection in adults with diabetic ketoacidosis (DKA). However, both CRP and the pro-inflammatory cytokines, which regulate CRP, can be elevated without infection. Our hypothesis was that CRP is increased in young patients with severe DKA, even in the absence of an infection, and may serve as a marker for systemic inflammatory response syndrome (SIRS). In 7 patients with severe DKA without infection, we measured plasma CRP, IL-6, IL-1beta and TNF-alpha levels prior to, during, and following correction of DKA. CRP was significantly but transiently elevated in 4 of the patients prior to or during treatment of DKA, compared to their baseline values (96 hr after correction of DKA). There were significant positive relationships between CRP and both IL-6 and IL-1beta prior to treatment (p <0.05); between CRP and IL-6, IL-1beta, and TNF-alpha at 6 hr (p <0.05); and between CRP and IL-1beta at 24 hr (p <0.05). The results support the hypothesis that CRP is increased in some patients by severe DKA and its treatment, and that DKA can be associated with a non-infectious form of SIRS.</description><identifier>ISSN: 0091-7370</identifier><identifier>EISSN: 1550-8080</identifier><identifier>PMID: 14584758</identifier><identifier>CODEN: ACLSCP</identifier><language>eng</language><publisher>Philadelphia, PA: Institute for Clinical Science</publisher><subject>Adolescent ; Biological and medical sciences ; Biomarkers - blood ; C-Reactive Protein - analysis ; Child ; Diabetic Ketoacidosis - blood ; Diabetic Ketoacidosis - therapy ; Humans ; Interleukin-1 - blood ; Interleukin-6 - blood ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Systemic Inflammatory Response Syndrome - blood ; Time Factors ; Tumor Necrosis Factor-alpha - analysis</subject><ispartof>Annals of clinical and laboratory science, 2003-09, Vol.33 (4), p.435-442</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15393658$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14584758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DALTON, Rory R</creatorcontrib><creatorcontrib>HOFFMAN, William H</creatorcontrib><creatorcontrib>PASSMORE, Gregory G</creatorcontrib><creatorcontrib>MARTIN, S. Lee</creatorcontrib><title>Plasma C-reactive protein levels in severe diabetic ketoacidosis</title><title>Annals of clinical and laboratory science</title><addtitle>Ann Clin Lab Sci</addtitle><description>Elevated plasma levels of C-reactive protein (CRP) and IL-6 have been reported to be sensitive indicators of infection in adults with diabetic ketoacidosis (DKA). However, both CRP and the pro-inflammatory cytokines, which regulate CRP, can be elevated without infection. Our hypothesis was that CRP is increased in young patients with severe DKA, even in the absence of an infection, and may serve as a marker for systemic inflammatory response syndrome (SIRS). In 7 patients with severe DKA without infection, we measured plasma CRP, IL-6, IL-1beta and TNF-alpha levels prior to, during, and following correction of DKA. CRP was significantly but transiently elevated in 4 of the patients prior to or during treatment of DKA, compared to their baseline values (96 hr after correction of DKA). There were significant positive relationships between CRP and both IL-6 and IL-1beta prior to treatment (p <0.05); between CRP and IL-6, IL-1beta, and TNF-alpha at 6 hr (p <0.05); and between CRP and IL-1beta at 24 hr (p <0.05). The results support the hypothesis that CRP is increased in some patients by severe DKA and its treatment, and that DKA can be associated with a non-infectious form of SIRS.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Child</subject><subject>Diabetic Ketoacidosis - blood</subject><subject>Diabetic Ketoacidosis - therapy</subject><subject>Humans</subject><subject>Interleukin-1 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Systemic Inflammatory Response Syndrome - blood</subject><subject>Time Factors</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>0091-7370</issn><issn>1550-8080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz01LxDAQBuAgiruu_gXpRW-FJE2a5qYsfsGCHvRcZidTjKbbtdNd8N8bcMXTvIeHd2aOxFxZK8tGNvJYzKX0qnSVkzNxxvwhpfbGyFMxU8Y2xtlmLm5eEnAPxbIcCXCKeyq24zBR3BSJ9pS4yIlzGqkIEdY0RSw-aRoAYxg48rk46SAxXRzmQrzd370uH8vV88PT8nZVvuvaTWVYU9MZyHsrAxqRQIFtICgNLmgEkA6NxU6Tll3QtdUelQleOfS287paiOvf3nze1454avvISCnBhoYdt05VyllXZ3h5gLt1T6HdjrGH8bv9-zmDqwMARkjdCBuM_O9s5as6ux8tP2Ds</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>DALTON, Rory R</creator><creator>HOFFMAN, William H</creator><creator>PASSMORE, Gregory G</creator><creator>MARTIN, S. Lee</creator><general>Institute for Clinical Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Plasma C-reactive protein levels in severe diabetic ketoacidosis</title><author>DALTON, Rory R ; HOFFMAN, William H ; PASSMORE, Gregory G ; MARTIN, S. Lee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h267t-dbe8f4a45834a2ccea1a58ad12a7d2caa07c45cf2e20fd26529c14d917c95f923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Child</topic><topic>Diabetic Ketoacidosis - blood</topic><topic>Diabetic Ketoacidosis - therapy</topic><topic>Humans</topic><topic>Interleukin-1 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Systemic Inflammatory Response Syndrome - blood</topic><topic>Time Factors</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DALTON, Rory R</creatorcontrib><creatorcontrib>HOFFMAN, William H</creatorcontrib><creatorcontrib>PASSMORE, Gregory G</creatorcontrib><creatorcontrib>MARTIN, S. Lee</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical and laboratory science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DALTON, Rory R</au><au>HOFFMAN, William H</au><au>PASSMORE, Gregory G</au><au>MARTIN, S. Lee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma C-reactive protein levels in severe diabetic ketoacidosis</atitle><jtitle>Annals of clinical and laboratory science</jtitle><addtitle>Ann Clin Lab Sci</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>33</volume><issue>4</issue><spage>435</spage><epage>442</epage><pages>435-442</pages><issn>0091-7370</issn><eissn>1550-8080</eissn><coden>ACLSCP</coden><abstract>Elevated plasma levels of C-reactive protein (CRP) and IL-6 have been reported to be sensitive indicators of infection in adults with diabetic ketoacidosis (DKA). However, both CRP and the pro-inflammatory cytokines, which regulate CRP, can be elevated without infection. Our hypothesis was that CRP is increased in young patients with severe DKA, even in the absence of an infection, and may serve as a marker for systemic inflammatory response syndrome (SIRS). In 7 patients with severe DKA without infection, we measured plasma CRP, IL-6, IL-1beta and TNF-alpha levels prior to, during, and following correction of DKA. CRP was significantly but transiently elevated in 4 of the patients prior to or during treatment of DKA, compared to their baseline values (96 hr after correction of DKA). There were significant positive relationships between CRP and both IL-6 and IL-1beta prior to treatment (p <0.05); between CRP and IL-6, IL-1beta, and TNF-alpha at 6 hr (p <0.05); and between CRP and IL-1beta at 24 hr (p <0.05). The results support the hypothesis that CRP is increased in some patients by severe DKA and its treatment, and that DKA can be associated with a non-infectious form of SIRS.</abstract><cop>Philadelphia, PA</cop><pub>Institute for Clinical Science</pub><pmid>14584758</pmid><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Biomarkers - blood C-Reactive Protein - analysis Child Diabetic Ketoacidosis - blood Diabetic Ketoacidosis - therapy Humans Interleukin-1 - blood Interleukin-6 - blood Investigative techniques, diagnostic techniques (general aspects) Medical sciences Systemic Inflammatory Response Syndrome - blood Time Factors Tumor Necrosis Factor-alpha - analysis |
| title | Plasma C-reactive protein levels in severe diabetic ketoacidosis |
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