The role of α-tocopherol in preventing disease: from epidemiology to molecular events
The function of vitamin E has been attributed to its capacity to protect the organism against the attack of free radicals by acting as a lipid based radical chain breaking molecule. More recently, alternative non-antioxidant functions of vitamin E have been proposed and in particular that of a “gene...
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| Veröffentlicht in: | Molecular aspects of medicine 2003-12, Vol.24 (6), p.325-336 |
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| container_title | Molecular aspects of medicine |
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| creator | Azzi, A. Gysin, R. Kempná, P. Ricciarelli, R. Villacorta, L. Visarius, T. Zingg, J.-M. |
| description | The function of vitamin E has been attributed to its capacity to protect the organism against the attack of free radicals by acting as a lipid based radical chain breaking molecule. More recently, alternative non-antioxidant functions of vitamin E have been proposed and in particular that of a “gene regulator”. Effects of vitamin E have been observed at the level of mRNA or protein and could be consequent to regulation of gene transcription, mRNA stability, protein translation, protein stability and post-translational events. Given the high priority functions assigned to vitamin E, it can be speculated that it would be inefficient to consume it as a radical scavenger. Rather, it would be important to protect vitamin E through a network of cellular antioxidant defences, similarly to what occurs with proteins, nucleic acids and lipids. |
| doi_str_mv | 10.1016/S0098-2997(03)00028-1 |
| format | Article |
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More recently, alternative non-antioxidant functions of vitamin E have been proposed and in particular that of a “gene regulator”. Effects of vitamin E have been observed at the level of mRNA or protein and could be consequent to regulation of gene transcription, mRNA stability, protein translation, protein stability and post-translational events. Given the high priority functions assigned to vitamin E, it can be speculated that it would be inefficient to consume it as a radical scavenger. 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| ispartof | Molecular aspects of medicine, 2003-12, Vol.24 (6), p.325-336 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | alpha-Tocopherol - metabolism Animal Diseases - prevention & control Animals Antioxidants - metabolism Arteriosclerosis - prevention & control Ataxia - prevention & control Cardiovascular Diseases - epidemiology Cardiovascular Diseases - prevention & control Cell signaling Free Radicals - metabolism gamma-Tocopherol - metabolism Gene expression Gene Expression Regulation Humans Male Non-antioxidant Prostatic Neoplasms - prevention & control Protein kinase C Protein Processing, Post-Translational Proteins - metabolism RNA, Messenger - metabolism Signal Transduction Tocopherols Transcription, Genetic Vitamin E |
| title | The role of α-tocopherol in preventing disease: from epidemiology to molecular events |
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