Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer
Electrostatic spinning was applied to the preparation of drug-laden nonbiodegradable nanofiber for potential use in topical drug administration and wound healing. The specific aim of these studies was to assess whether these systems might be of interest as delivery systems for poorly water-soluble d...
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| Veröffentlicht in: | Journal of controlled release 2003-10, Vol.92 (3), p.349-360 |
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| creator | Verreck, Geert Chun, Iksoo Rosenblatt, Joel Peeters, Jef Dijck, Alex Van Mensch, Jurgen Noppe, Marc Brewster, Marcus E. |
| description | Electrostatic spinning was applied to the preparation of drug-laden nonbiodegradable nanofiber for potential use in topical drug administration and wound healing. The specific aim of these studies was to assess whether these systems might be of interest as delivery systems for poorly water-soluble drugs. Itraconazole and ketanserin were selected as model compounds while a segmented polyurethane (PU) was selected as the nonbiodegradable polymer. For both itraconazole and ketanserin, an amorphous nanodispersion with PU was obtained when the drug/polymer solutions were electrospun from dimethylformide (DMF) and dimethylacetamide (DMAc), respectively. The collected nonwoven fabrics were shown to release the drugs at various rates and profiles based on the nanofiber morphology and drug content. Data were generated using a specially designed release apparatus based around a rotating cylinder. At low drug loading, itraconazole was released from the nanofibers as a linear function of the square root of time suggesting Fickian kinetics. No initial drug burst was observed. A biphasic release pattern was observed for ketanserin in which two sequential linear components were noted. These release phases may be temporally correlated with (1) drug diffusion through the polymer and (2) drug diffusion through formed aqueous pores. |
| doi_str_mv | 10.1016/S0168-3659(03)00342-0 |
| format | Article |
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The specific aim of these studies was to assess whether these systems might be of interest as delivery systems for poorly water-soluble drugs. Itraconazole and ketanserin were selected as model compounds while a segmented polyurethane (PU) was selected as the nonbiodegradable polymer. For both itraconazole and ketanserin, an amorphous nanodispersion with PU was obtained when the drug/polymer solutions were electrospun from dimethylformide (DMF) and dimethylacetamide (DMAc), respectively. The collected nonwoven fabrics were shown to release the drugs at various rates and profiles based on the nanofiber morphology and drug content. Data were generated using a specially designed release apparatus based around a rotating cylinder. At low drug loading, itraconazole was released from the nanofibers as a linear function of the square root of time suggesting Fickian kinetics. No initial drug burst was observed. A biphasic release pattern was observed for ketanserin in which two sequential linear components were noted. These release phases may be temporally correlated with (1) drug diffusion through the polymer and (2) drug diffusion through formed aqueous pores.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/S0168-3659(03)00342-0</identifier><identifier>PMID: 14568415</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Calorimetry, Differential Scanning ; Delayed-Action Preparations - chemistry ; dimethylacetamide ; dimethylformide ; Drug Carriers - chemistry ; Drug Delivery Systems - methods ; Electrostatic spinning ; General pharmacology ; Itraconazole ; Itraconazole - administration & dosage ; Itraconazole - pharmacokinetics ; Ketanserin ; Ketanserin - administration & dosage ; Ketanserin - pharmacokinetics ; Kinetics ; Medical sciences ; Microscopy, Electron, Scanning ; Molecular Structure ; Nanofibers ; Nanotechnology - methods ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Phase Transition ; Polymers - chemistry ; Polyurethane ; Polyurethanes - chemistry ; Static Electricity</subject><ispartof>Journal of controlled release, 2003-10, Vol.92 (3), p.349-360</ispartof><rights>2003 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-920f5fb8d4ab6305dd047bf3fc49e288edef7125607965b6f5a59c22ccb62dc63</citedby><cites>FETCH-LOGICAL-c422t-920f5fb8d4ab6305dd047bf3fc49e288edef7125607965b6f5a59c22ccb62dc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0168-3659(03)00342-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15206052$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14568415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verreck, Geert</creatorcontrib><creatorcontrib>Chun, Iksoo</creatorcontrib><creatorcontrib>Rosenblatt, Joel</creatorcontrib><creatorcontrib>Peeters, Jef</creatorcontrib><creatorcontrib>Dijck, Alex Van</creatorcontrib><creatorcontrib>Mensch, Jurgen</creatorcontrib><creatorcontrib>Noppe, Marc</creatorcontrib><creatorcontrib>Brewster, Marcus E.</creatorcontrib><title>Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Electrostatic spinning was applied to the preparation of drug-laden nonbiodegradable nanofiber for potential use in topical drug administration and wound healing. The specific aim of these studies was to assess whether these systems might be of interest as delivery systems for poorly water-soluble drugs. Itraconazole and ketanserin were selected as model compounds while a segmented polyurethane (PU) was selected as the nonbiodegradable polymer. For both itraconazole and ketanserin, an amorphous nanodispersion with PU was obtained when the drug/polymer solutions were electrospun from dimethylformide (DMF) and dimethylacetamide (DMAc), respectively. The collected nonwoven fabrics were shown to release the drugs at various rates and profiles based on the nanofiber morphology and drug content. Data were generated using a specially designed release apparatus based around a rotating cylinder. At low drug loading, itraconazole was released from the nanofibers as a linear function of the square root of time suggesting Fickian kinetics. No initial drug burst was observed. A biphasic release pattern was observed for ketanserin in which two sequential linear components were noted. These release phases may be temporally correlated with (1) drug diffusion through the polymer and (2) drug diffusion through formed aqueous pores.</description><subject>Biological and medical sciences</subject><subject>Calorimetry, Differential Scanning</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>dimethylacetamide</subject><subject>dimethylformide</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems - methods</subject><subject>Electrostatic spinning</subject><subject>General pharmacology</subject><subject>Itraconazole</subject><subject>Itraconazole - administration & dosage</subject><subject>Itraconazole - pharmacokinetics</subject><subject>Ketanserin</subject><subject>Ketanserin - administration & dosage</subject><subject>Ketanserin - pharmacokinetics</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Molecular Structure</subject><subject>Nanofibers</subject><subject>Nanotechnology - methods</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Phase Transition</subject><subject>Polymers - chemistry</subject><subject>Polyurethane</subject><subject>Polyurethanes - chemistry</subject><subject>Static Electricity</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEQgIMo7jj6E5RcFAVb8-7uk8jiY2HBg3oOeVTWSHfSJt3K3vzpZnYG97gQklD5UlXJh9BTSt5QQtXbr20aOq7k-JLwV4RwwTpyD-3o0PNOjKO8j3b_kTP0qNafhBDJRf8QnVEh1SCo3KG_F8nlsuRi1pgTzgH7sl1VHBM2bczt7EfeKq6rWaFF14xhAreWXJct4WRSDtFCqdjleckV_CGHwX8aXrqYap42O8FrnHKyMXu4KsabFsFLnq5nKI_Rg2CmCk9O6x59__jh2_nn7vLLp4vz95edE4yt3chIkMEOXhirOJHeE9HbwIMTI7BhAA-hp0wq0o9KWhWkkaNjzDmrmHeK79GLY96l5F8b1FXPsTqYJpOgPVD3lFNFe3knSIdR8laqgfIIuvYZtUDQS4mzKdeaEn1wpG8c6YMATbi-cdQ2e_TsVGCzM_jbWycpDXh-Akx1ZgrFJBfrLScZUUQeGnh35KD92-8IRVcXITnwsTRF2ud4Ryv_AHIQsNY</recordid><startdate>20031030</startdate><enddate>20031030</enddate><creator>Verreck, Geert</creator><creator>Chun, Iksoo</creator><creator>Rosenblatt, Joel</creator><creator>Peeters, Jef</creator><creator>Dijck, Alex Van</creator><creator>Mensch, Jurgen</creator><creator>Noppe, Marc</creator><creator>Brewster, Marcus E.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20031030</creationdate><title>Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer</title><author>Verreck, Geert ; Chun, Iksoo ; Rosenblatt, Joel ; Peeters, Jef ; Dijck, Alex Van ; Mensch, Jurgen ; Noppe, Marc ; Brewster, Marcus E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-920f5fb8d4ab6305dd047bf3fc49e288edef7125607965b6f5a59c22ccb62dc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Calorimetry, Differential Scanning</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>dimethylacetamide</topic><topic>dimethylformide</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems - methods</topic><topic>Electrostatic spinning</topic><topic>General pharmacology</topic><topic>Itraconazole</topic><topic>Itraconazole - administration & dosage</topic><topic>Itraconazole - pharmacokinetics</topic><topic>Ketanserin</topic><topic>Ketanserin - administration & dosage</topic><topic>Ketanserin - pharmacokinetics</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Molecular Structure</topic><topic>Nanofibers</topic><topic>Nanotechnology - methods</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Phase Transition</topic><topic>Polymers - chemistry</topic><topic>Polyurethane</topic><topic>Polyurethanes - chemistry</topic><topic>Static Electricity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verreck, Geert</creatorcontrib><creatorcontrib>Chun, Iksoo</creatorcontrib><creatorcontrib>Rosenblatt, Joel</creatorcontrib><creatorcontrib>Peeters, Jef</creatorcontrib><creatorcontrib>Dijck, Alex Van</creatorcontrib><creatorcontrib>Mensch, Jurgen</creatorcontrib><creatorcontrib>Noppe, Marc</creatorcontrib><creatorcontrib>Brewster, Marcus E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verreck, Geert</au><au>Chun, Iksoo</au><au>Rosenblatt, Joel</au><au>Peeters, Jef</au><au>Dijck, Alex Van</au><au>Mensch, Jurgen</au><au>Noppe, Marc</au><au>Brewster, Marcus E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2003-10-30</date><risdate>2003</risdate><volume>92</volume><issue>3</issue><spage>349</spage><epage>360</epage><pages>349-360</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>Electrostatic spinning was applied to the preparation of drug-laden nonbiodegradable nanofiber for potential use in topical drug administration and wound healing. The specific aim of these studies was to assess whether these systems might be of interest as delivery systems for poorly water-soluble drugs. Itraconazole and ketanserin were selected as model compounds while a segmented polyurethane (PU) was selected as the nonbiodegradable polymer. For both itraconazole and ketanserin, an amorphous nanodispersion with PU was obtained when the drug/polymer solutions were electrospun from dimethylformide (DMF) and dimethylacetamide (DMAc), respectively. The collected nonwoven fabrics were shown to release the drugs at various rates and profiles based on the nanofiber morphology and drug content. Data were generated using a specially designed release apparatus based around a rotating cylinder. At low drug loading, itraconazole was released from the nanofibers as a linear function of the square root of time suggesting Fickian kinetics. No initial drug burst was observed. A biphasic release pattern was observed for ketanserin in which two sequential linear components were noted. These release phases may be temporally correlated with (1) drug diffusion through the polymer and (2) drug diffusion through formed aqueous pores.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>14568415</pmid><doi>10.1016/S0168-3659(03)00342-0</doi><tpages>12</tpages></addata></record> |
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| ispartof | Journal of controlled release, 2003-10, Vol.92 (3), p.349-360 |
| issn | 0168-3659 1873-4995 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Calorimetry, Differential Scanning Delayed-Action Preparations - chemistry dimethylacetamide dimethylformide Drug Carriers - chemistry Drug Delivery Systems - methods Electrostatic spinning General pharmacology Itraconazole Itraconazole - administration & dosage Itraconazole - pharmacokinetics Ketanserin Ketanserin - administration & dosage Ketanserin - pharmacokinetics Kinetics Medical sciences Microscopy, Electron, Scanning Molecular Structure Nanofibers Nanotechnology - methods Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phase Transition Polymers - chemistry Polyurethane Polyurethanes - chemistry Static Electricity |
| title | Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer |
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