Epigenetic inactivation of RASSF1A candidate tumor suppressor gene at 3p21.3 in brain tumors

The human Ras association domain family 1A ( RASSF1A ) gene, recently isolated from the lung and breast tumor suppressor locus 3p21.3, is highly methylated in primary lung, breast, nasopharyngeal and other tumors, and re-expression of RASSF1A suppresses the growth of several types of cancer cells. E...

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Veröffentlicht in:	Oncogene 2003-10, Vol.22 (49), p.7862-7865
Hauptverfasser:	Horiguchi, Keishi, Tomizawa, Yoshio, Tosaka, Masahiko, Ishiuchi, Shogo, Kurihara, Hideyuki, Mori, Masatomo, Saito, Nobuhito
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Azacitidine - analogs & derivatives Azacitidine - pharmacology Azacytidine Biological and medical sciences Brain cancer Brain Neoplasms - genetics Brain tumors Breast cancer Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome 3 Chromosomes Chromosomes, Human, Pair 3 CpG Islands DNA Methylation Epigenetics Fundamental and applied biological sciences. Psychology Genes Genes, Tumor Suppressor Glioma Glioma - genetics Glioma cells Human Genetics Humans Internal Medicine Medical sciences Medicine Medicine & Public Health Medulloblastoma Medulloblastoma - genetics Molecular and cellular biology Neoplasm Proteins - genetics Neurology Oncology Polymerase chain reaction Promoter Regions, Genetic RASSF1A gene short-report Tumor suppressor genes Tumor Suppressor Proteins Tumorigenesis Tumors Tumors of the nervous system. Phacomatoses
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