TGF-β cytokines increase senescence-associated beta-galactosidase activity in human prostate basal cells by supporting differentiation processes, but not cellular senescence

The family of transforming growth factors betas ( TGF- βs) comprises molecules involved in growth inhibition, stress-induced premature senescence, epithelial mesenchymal transition and differentiation processes. The aim of this study was to clarify the effect of long term exposure of human prostate...

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Veröffentlicht in:	Experimental gerontology 2003-10, Vol.38 (10), p.1179-1188
Hauptverfasser:	Untergasser, G., Gander, R., Rumpold, H., Heinrich, E., Plas, E., Berger, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged beta-Galactosidase - drug effects beta-Galactosidase - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Differentiation - drug effects Cell Division - drug effects Cells, Cultured Cellular senescence Cellular Senescence - drug effects Cellular Senescence - genetics Differentiation Gene Expression Regulation - drug effects Genes, p16 Human prostate Humans Male Neuroendocrine cells Prostate - cytology Prostate - drug effects Prostate - enzymology Recombinant Proteins - pharmacology SA-beta galactosidase TGF-β Transforming Growth Factor beta - pharmacology Up-Regulation - drug effects
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