Use of Tandem Mass Spectrometry for Multianalyte Screening of Dried Blood Specimens from Newborns

Over the past decade laboratories that test for metabolic disorders have introduced tandem mass spectrometry (MS/MS), which is more sensitive, specific, reliable, and comprehensive than traditional assays, into their newborn-screening programs. MS/MS is rapidly replacing these one-analysis, one-meta...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2003-11, Vol.49 (11), p.1797-1817
Hauptverfasser:	Chace, Donald H, Kalas, Theodore A, Naylor, Edwin W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Metabolism, Inborn Errors - blood Amino acids Amino Acids - blood Biological and medical sciences Blood Blood Specimen Collection Carnitine - analogs & derivatives Carnitine - blood Disease Fatty acids Hematologic Tests - methods Humans Infant, Newborn Investigative techniques, diagnostic techniques (general aspects) Lipid Metabolism, Inborn Errors - blood Mass spectrometry Mass Spectrometry - methods Medical sciences Medical screening Metabolic diseases Metabolic disorders Metabolites Organic acids Oxidation Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phenylketonuria Scientific imaging Urine
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