Role of the extracellular matrix in morphogenesis
The extracellular matrix is a complex, dynamic and critical component of all tissues. It functions as a scaffold for tissue morphogenesis, provides cues for cell proliferation and differentiation, promotes the maintenance of differentiated tissues and enhances the repair response after injury. Vario...
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| Veröffentlicht in: | Current opinion in biotechnology 2003-10, Vol.14 (5), p.526-532 |
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| container_title | Current opinion in biotechnology |
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| creator | Kleinman, Hynda K Philp, Deborah Hoffman, Matthew P |
| description | The extracellular matrix is a complex, dynamic and critical component of all tissues. It functions as a scaffold for tissue morphogenesis, provides cues for cell proliferation and differentiation, promotes the maintenance of differentiated tissues and enhances the repair response after injury. Various amounts and types of collagens, adhesion molecules, proteoglycans, growth factors and cytokines or chemokines are present in the tissue- and temporal-specific extracellular matrices. Tissue morphogenesis is mediated by multiple extracellular matrix components and by multiple active sites on some of these components. Biologically active extracellular matrix components may have use in tissue repair, regeneration and engineering, and in programming stem cells for tissue replacement. |
| doi_str_mv | 10.1016/j.copbio.2003.08.002 |
| format | Article |
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| ispartof | Current opinion in biotechnology, 2003-10, Vol.14 (5), p.526-532 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Cell Culture Techniques Cell Differentiation Cell Line Extracellular Matrix - physiology Extracellular Matrix Proteins - physiology Fibroblast Growth Factors - physiology Mice Mice, Knockout Morphogenesis Organ Culture Techniques Regeneration Stem Cells - physiology |
| title | Role of the extracellular matrix in morphogenesis |
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