Monosodium Glutamate and Sweet Taste: Generalization of Conditioned Taste Aversion between Glutamate and Sweet Stimuli in Rats
Even though monosodium glutamate (MSG) is a prototypical umami substance, previous studies reported that a conditioned taste aversion (CTA) to MSG, mixed with amiloride to block the taste of sodium, generalizes to sucrose. These findings suggest that the taste of glutamate mimics the taste of sucros...
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| Veröffentlicht in: | Chemical senses 2003-09, Vol.28 (7), p.631-641 |
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| creator | Heyer, B.R. Taylor-Burds, C.C. Tran, L.H. Delay, E.R. |
| description | Even though monosodium glutamate (MSG) is a prototypical umami substance, previous studies reported that a conditioned taste aversion (CTA) to MSG, mixed with amiloride to block the taste of sodium, generalizes to sucrose. These findings suggest that the taste of glutamate mimics the taste of sucrose and raise the question of whether glutamate has a broadly tuned sweet taste component. To test this hypothesis, CTA experiments were conducted to test for generalization between MSG and several sweet stimuli: sucrose, glucose, maltose, saccharin and SC-45647. Strong bidirectional generalization was seen between MSG mixed with amiloride and sucrose, glucose, saccharin and SC-45647. Weak generalization was seen between MSG and maltose, and sucrose and maltose. None of the CTAs generalized to NMDA. These findings support the hypothesis that the taste of MSG has broadly tuned, sweet-like characteristics, possibly due to the convergence of afferent signals for MSG, natural sugars and artificial sweeteners. |
| doi_str_mv | 10.1093/chemse/bjg056 |
| format | Article |
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These findings suggest that the taste of glutamate mimics the taste of sucrose and raise the question of whether glutamate has a broadly tuned sweet taste component. To test this hypothesis, CTA experiments were conducted to test for generalization between MSG and several sweet stimuli: sucrose, glucose, maltose, saccharin and SC-45647. Strong bidirectional generalization was seen between MSG mixed with amiloride and sucrose, glucose, saccharin and SC-45647. Weak generalization was seen between MSG and maltose, and sucrose and maltose. None of the CTAs generalized to NMDA. These findings support the hypothesis that the taste of MSG has broadly tuned, sweet-like characteristics, possibly due to the convergence of afferent signals for MSG, natural sugars and artificial sweeteners.</description><identifier>ISSN: 0379-864X</identifier><identifier>ISSN: 1464-3553</identifier><identifier>EISSN: 1464-3553</identifier><identifier>DOI: 10.1093/chemse/bjg056</identifier><identifier>PMID: 14578125</identifier><identifier>CODEN: CHSED8</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Amiloride - pharmacology ; Animals ; Avoidance Learning - physiology ; conditioned taste aversion ; Flavoring Agents - pharmacology ; Glucose - pharmacology ; Glutamic Acid - pharmacology ; Guanidines - pharmacology ; Male ; Maltose - pharmacology ; monosodium glutamate ; Rats ; Rats, Sprague-Dawley ; Saccharin - pharmacology ; Sodium Glutamate - pharmacology ; Sucrose - pharmacology ; sweet stimuli ; sweet taste ; Sweetening Agents - pharmacology ; Taste - drug effects ; Taste - physiology ; umami</subject><ispartof>Chemical senses, 2003-09, Vol.28 (7), p.631-641</ispartof><rights>Copyright Oxford University Press(England) Sep 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-f61d7e34b60a3fe8c615611b2409ca0ee029822d0ed3433c1731204a47dd729f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14578125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heyer, B.R.</creatorcontrib><creatorcontrib>Taylor-Burds, C.C.</creatorcontrib><creatorcontrib>Tran, L.H.</creatorcontrib><creatorcontrib>Delay, E.R.</creatorcontrib><title>Monosodium Glutamate and Sweet Taste: Generalization of Conditioned Taste Aversion between Glutamate and Sweet Stimuli in Rats</title><title>Chemical senses</title><addtitle>Chem. Senses</addtitle><description>Even though monosodium glutamate (MSG) is a prototypical umami substance, previous studies reported that a conditioned taste aversion (CTA) to MSG, mixed with amiloride to block the taste of sodium, generalizes to sucrose. These findings suggest that the taste of glutamate mimics the taste of sucrose and raise the question of whether glutamate has a broadly tuned sweet taste component. To test this hypothesis, CTA experiments were conducted to test for generalization between MSG and several sweet stimuli: sucrose, glucose, maltose, saccharin and SC-45647. Strong bidirectional generalization was seen between MSG mixed with amiloride and sucrose, glucose, saccharin and SC-45647. Weak generalization was seen between MSG and maltose, and sucrose and maltose. None of the CTAs generalized to NMDA. These findings support the hypothesis that the taste of MSG has broadly tuned, sweet-like characteristics, possibly due to the convergence of afferent signals for MSG, natural sugars and artificial sweeteners.</description><subject>Amiloride - pharmacology</subject><subject>Animals</subject><subject>Avoidance Learning - physiology</subject><subject>conditioned taste aversion</subject><subject>Flavoring Agents - pharmacology</subject><subject>Glucose - pharmacology</subject><subject>Glutamic Acid - pharmacology</subject><subject>Guanidines - pharmacology</subject><subject>Male</subject><subject>Maltose - pharmacology</subject><subject>monosodium glutamate</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Saccharin - pharmacology</subject><subject>Sodium Glutamate - pharmacology</subject><subject>Sucrose - pharmacology</subject><subject>sweet stimuli</subject><subject>sweet taste</subject><subject>Sweetening Agents - pharmacology</subject><subject>Taste - drug effects</subject><subject>Taste - physiology</subject><subject>umami</subject><issn>0379-864X</issn><issn>1464-3553</issn><issn>1464-3553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1rFDEYBvAgit1Wj14lePA2Nl-TTLy1i26VimArW3oJmck7mnUmqZNM_Tj4tzvDLBZE8BTC-8sDeR-EnlDyghLNj5vP0Cc4rnefSCnvoRUVUhS8LPl9tCJc6aKS4uoAHaa0I4QKzqqH6ICKUlWUlSv0610MMUXnxx5vujHb3mbANjh88Q0g40ubMrzEGwgw2M7_tNnHgGOL1zE4P1_ALQif3MKQ5mkNeXob_pl3kX0_dh77gD_YnB6hB63tEjzen0fo4-tXl-uz4vz95s365LxohCa5aCV1CrioJbG8haqRtJSU1kwQ3VgCQJiuGHMEHBecN1RxyoiwQjmnmG75EXq-5N4M8esIKZvepwa6zgaIYzKKcqKoJP-FVFMphZjhs7_gLo5DmD4xGc1KpvWMigU1Q0xpgNbcDL63ww9DiZnrM0t9Zqlv8k_3oWPdg7vT-77uAv208e9_5nb4YqTiqjRnV9fmequ0eLs9NVv-G1Hbp4k</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Heyer, B.R.</creator><creator>Taylor-Burds, C.C.</creator><creator>Tran, L.H.</creator><creator>Delay, E.R.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Monosodium Glutamate and Sweet Taste: Generalization of Conditioned Taste Aversion between Glutamate and Sweet Stimuli in Rats</title><author>Heyer, B.R. ; Taylor-Burds, C.C. ; Tran, L.H. ; Delay, E.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-f61d7e34b60a3fe8c615611b2409ca0ee029822d0ed3433c1731204a47dd729f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amiloride - pharmacology</topic><topic>Animals</topic><topic>Avoidance Learning - physiology</topic><topic>conditioned taste aversion</topic><topic>Flavoring Agents - pharmacology</topic><topic>Glucose - pharmacology</topic><topic>Glutamic Acid - pharmacology</topic><topic>Guanidines - pharmacology</topic><topic>Male</topic><topic>Maltose - pharmacology</topic><topic>monosodium glutamate</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Saccharin - pharmacology</topic><topic>Sodium Glutamate - pharmacology</topic><topic>Sucrose - pharmacology</topic><topic>sweet stimuli</topic><topic>sweet taste</topic><topic>Sweetening Agents - pharmacology</topic><topic>Taste - drug effects</topic><topic>Taste - physiology</topic><topic>umami</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heyer, B.R.</creatorcontrib><creatorcontrib>Taylor-Burds, C.C.</creatorcontrib><creatorcontrib>Tran, L.H.</creatorcontrib><creatorcontrib>Delay, E.R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical senses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heyer, B.R.</au><au>Taylor-Burds, C.C.</au><au>Tran, L.H.</au><au>Delay, E.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monosodium Glutamate and Sweet Taste: Generalization of Conditioned Taste Aversion between Glutamate and Sweet Stimuli in Rats</atitle><jtitle>Chemical senses</jtitle><addtitle>Chem. Senses</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>28</volume><issue>7</issue><spage>631</spage><epage>641</epage><pages>631-641</pages><issn>0379-864X</issn><issn>1464-3553</issn><eissn>1464-3553</eissn><coden>CHSED8</coden><abstract>Even though monosodium glutamate (MSG) is a prototypical umami substance, previous studies reported that a conditioned taste aversion (CTA) to MSG, mixed with amiloride to block the taste of sodium, generalizes to sucrose. These findings suggest that the taste of glutamate mimics the taste of sucrose and raise the question of whether glutamate has a broadly tuned sweet taste component. To test this hypothesis, CTA experiments were conducted to test for generalization between MSG and several sweet stimuli: sucrose, glucose, maltose, saccharin and SC-45647. Strong bidirectional generalization was seen between MSG mixed with amiloride and sucrose, glucose, saccharin and SC-45647. Weak generalization was seen between MSG and maltose, and sucrose and maltose. None of the CTAs generalized to NMDA. These findings support the hypothesis that the taste of MSG has broadly tuned, sweet-like characteristics, possibly due to the convergence of afferent signals for MSG, natural sugars and artificial sweeteners.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>14578125</pmid><doi>10.1093/chemse/bjg056</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Amiloride - pharmacology Animals Avoidance Learning - physiology conditioned taste aversion Flavoring Agents - pharmacology Glucose - pharmacology Glutamic Acid - pharmacology Guanidines - pharmacology Male Maltose - pharmacology monosodium glutamate Rats Rats, Sprague-Dawley Saccharin - pharmacology Sodium Glutamate - pharmacology Sucrose - pharmacology sweet stimuli sweet taste Sweetening Agents - pharmacology Taste - drug effects Taste - physiology umami |
| title | Monosodium Glutamate and Sweet Taste: Generalization of Conditioned Taste Aversion between Glutamate and Sweet Stimuli in Rats |
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