Prospects for gene therapy using haemopoietic stem cells
Gene therapy has thus far promised much and delivered little. Much of this has been due to deficiencies in the reagents and methodologies employed in early clinical trials. Recent technological advances in vectors and haemopoietic stem cell manipulation, coupled with improved pre-clinical assays of...
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| Veröffentlicht in: | Best practice & research. Clinical haematology 2001-12, Vol.14 (4), p.823-834 |
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| container_title | Best practice & research. Clinical haematology |
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| creator | Fairbairn, Leslie J Ewing, Joanne C |
| description | Gene therapy has thus far promised much and delivered little. Much of this has been due to deficiencies in the reagents and methodologies employed in early clinical trials. Recent technological advances in vectors and haemopoietic stem cell manipulation, coupled with improved pre-clinical assays of gene transfer and expression in re-populating stem cells give cause for greater optimism. Here we review these advances and indicate areas requiring further development before clinical gene therapy in the haemopoietic system becomes a widely applicable treatment modality. |
| doi_str_mv | 10.1053/beha.2001.0175 |
| format | Article |
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Much of this has been due to deficiencies in the reagents and methodologies employed in early clinical trials. Recent technological advances in vectors and haemopoietic stem cell manipulation, coupled with improved pre-clinical assays of gene transfer and expression in re-populating stem cells give cause for greater optimism. Here we review these advances and indicate areas requiring further development before clinical gene therapy in the haemopoietic system becomes a widely applicable treatment modality.</description><identifier>ISSN: 1521-6926</identifier><identifier>EISSN: 1532-1924</identifier><identifier>DOI: 10.1053/beha.2001.0175</identifier><identifier>PMID: 11924924</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; clinical trial ; cytokine ; gene therapy ; Genetic Therapy - methods ; Genetic Vectors - genetics ; Genetic Vectors - therapeutic use ; Hematopoietic Stem Cells - metabolism ; Humans ; pseudotyping ; retroviral vector ; Transduction, Genetic - methods ; Transduction, Genetic - trends</subject><ispartof>Best practice & research. 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Clinical haematology</title><addtitle>Best Pract Res Clin Haematol</addtitle><description>Gene therapy has thus far promised much and delivered little. Much of this has been due to deficiencies in the reagents and methodologies employed in early clinical trials. Recent technological advances in vectors and haemopoietic stem cell manipulation, coupled with improved pre-clinical assays of gene transfer and expression in re-populating stem cells give cause for greater optimism. Here we review these advances and indicate areas requiring further development before clinical gene therapy in the haemopoietic system becomes a widely applicable treatment modality.</description><subject>Animals</subject><subject>clinical trial</subject><subject>cytokine</subject><subject>gene therapy</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors - genetics</subject><subject>Genetic Vectors - therapeutic use</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Humans</subject><subject>pseudotyping</subject><subject>retroviral vector</subject><subject>Transduction, Genetic - methods</subject><subject>Transduction, Genetic - trends</subject><issn>1521-6926</issn><issn>1532-1924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtLxDAQh4Mo7rp69Sg9eWvN5NE2R1l8wYIe9BySdLob2T5MWsH_3pZd8CQMzBy--THzEXINNAMq-Z3FnckYpZBRKOQJWYLkLAXFxOk8M0hzxfIFuYjxk1LOFePnZAEzMNWSlG-hiz26ISZ1F5IttpgMOwym_0nG6NttsjPYdH3ncfAuiQM2icP9Pl6Ss9rsI14d-4p8PD68r5_TzevTy_p-kzou6JCaXBRgJUNQ1pUit6XNmeXUKVkUCpVUtBaVk9xKMIIJqipQtbQGjBXGIV-R20NuH7qvEeOgGx_nC0yL3Rh1AZzmOWUTmB1AN30UA9a6D74x4UcD1bMrPbvSsys9u5oWbo7Jo22w-sOPciagPAA4_fftMejoPLYOKx8mY7rq_H_Zvw86d4A</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Fairbairn, Leslie J</creator><creator>Ewing, Joanne C</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Prospects for gene therapy using haemopoietic stem cells</title><author>Fairbairn, Leslie J ; Ewing, Joanne C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-a6471b52e19bc846b8b62b30c95779e9590f4dc53b51a42409d19f5ba1ab4ace3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>clinical trial</topic><topic>cytokine</topic><topic>gene therapy</topic><topic>Genetic Therapy - methods</topic><topic>Genetic Vectors - genetics</topic><topic>Genetic Vectors - therapeutic use</topic><topic>Hematopoietic Stem Cells - metabolism</topic><topic>Humans</topic><topic>pseudotyping</topic><topic>retroviral vector</topic><topic>Transduction, Genetic - methods</topic><topic>Transduction, Genetic - trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fairbairn, Leslie J</creatorcontrib><creatorcontrib>Ewing, Joanne C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Best practice & research. 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Recent technological advances in vectors and haemopoietic stem cell manipulation, coupled with improved pre-clinical assays of gene transfer and expression in re-populating stem cells give cause for greater optimism. Here we review these advances and indicate areas requiring further development before clinical gene therapy in the haemopoietic system becomes a widely applicable treatment modality.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>11924924</pmid><doi>10.1053/beha.2001.0175</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1521-6926 |
| ispartof | Best practice & research. Clinical haematology, 2001-12, Vol.14 (4), p.823-834 |
| issn | 1521-6926 1532-1924 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals clinical trial cytokine gene therapy Genetic Therapy - methods Genetic Vectors - genetics Genetic Vectors - therapeutic use Hematopoietic Stem Cells - metabolism Humans pseudotyping retroviral vector Transduction, Genetic - methods Transduction, Genetic - trends |
| title | Prospects for gene therapy using haemopoietic stem cells |
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