Renal tubular regeneration by bone marrow-derived cells in a girl after bone marrow transplantation
Recent studies have indicated that bone marrow cells can contribute to regeneration of the kidney in experimental models. However, renal regeneration by apparent bone marrow-derived cells has not been shown previously in humans. The authors here report on a 7-year-old girl who received whole bone ma...
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| Veröffentlicht in: | American journal of kidney diseases 2003-11, Vol.42 (5), p.E10-E12 |
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| container_issue | 5 |
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| container_title | American journal of kidney diseases |
| container_volume | 42 |
| creator | Nishida, Masashi Kawakatsu, Hidekazu Shiraishi, Isao Fujimoto, Shin-ichiro Gotoh, Takahiro Urata, Yoji Ono, Takahiko Hamaoka, Kenji |
| description | Recent studies have indicated that bone marrow cells can contribute to regeneration of the kidney in experimental models. However, renal regeneration by apparent bone marrow-derived cells has not been shown previously in humans. The authors here report on a 7-year-old girl who received whole bone marrow transplantation from a male donor, and the contribution of bone marrow cells to the regeneration after renal damage was shown by in situ hybridization for the Y chromosome on autopsy specimens of the kidney. This observation suggests the clinical potential of bone marrow cells as a therapeutic option for renal injury. |
| doi_str_mv | 10.1053/S0272-6386(03)01021-7 |
| format | Article |
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| fulltext | fulltext |
| identifier | EISSN: 1523-6838 |
| ispartof | American journal of kidney diseases, 2003-11, Vol.42 (5), p.E10-E12 |
| issn | 1523-6838 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Bone Marrow Transplantation - adverse effects Child Chromosomes, Human, Y Epstein-Barr Virus Infections - complications Fatal Outcome Female Graft vs Host Disease - complications Graft vs Host Disease - drug therapy Humans In Situ Hybridization, Fluorescence Kidney Tubules - physiology Multiple Organ Failure - etiology Regeneration - genetics Regeneration - physiology |
| title | Renal tubular regeneration by bone marrow-derived cells in a girl after bone marrow transplantation |
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