Genetic cause of hyperglycaemia and response to treatment in diabetes

Type 2 diabetes shows evidence of underlying heterogeneity. No studies have assessed whether different causes for diabetes change the response to oral hypoglycaemic therapy. In a few cases, patients with diabetes caused by mutations in the hepatocyte nuclear factor 1α (HNF-1α) gene have been describ...

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Veröffentlicht in:	The Lancet (British edition) 2003-10, Vol.362 (9392), p.1275-1281
Hauptverfasser:	Pearson, Ewan R, Starkey, Bryan J, Powell, Roy J, Gribble, Fiona M, Clark, Penny M, Hattersley, Andrew T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged ATP-Binding Cassette Transporters - drug effects ATP-Binding Cassette Transporters - physiology Biological and medical sciences Blood Glucose - analysis Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus - blood Diabetes Mellitus - drug therapy Diabetes Mellitus - genetics Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics DNA-Binding Proteins Drug dosages Drug therapy Fasting Fasting - blood Female General and cellular metabolism. Vitamins Genetics Gliclazide - pharmacology Gliclazide - therapeutic use Glucose Hepatocyte Nuclear Factor 1 Hepatocyte Nuclear Factor 1-alpha Hepatocyte Nuclear Factor 1-beta Heterogeneity Humans Hyperglycemia Hyperglycemia - blood Hyperglycemia - genetics Hypoglycemia Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin Intravenous administration Laboratory testing Male Medical sciences Medical treatment Metabolism Metabolites Metformin Metformin - pharmacology Metformin - therapeutic use Middle Aged Motivation Mutation Nuclear Proteins Patients Pharmacology Pharmacology. Drug treatments Potassium Channels - drug effects Potassium Channels - physiology Potassium Channels, Inwardly Rectifying Receptors, Drug - drug effects Receptors, Drug - physiology Reduction Sensitivity analysis Sulfonylurea Receptors Systematic review Tolbutamide Transcription Factors - genetics
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