Immunoscintigraphy of septic loosening of knee endoprosthesis: a retrospective evaluation of the antigranulocyte antibody BW 250/183
Immunoscintigraphy with the use of the antigranulocyte antibody BW 250/183 is a reliable method for detecting infection, especially in septic loosening of hip prostheses, for which purpose quantitative interpretation of the time-activity course is employed. Therefore, we retrospectively studied whet...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2003-11, Vol.30 (11), p.1463-1466 |
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| container_title | European journal of nuclear medicine and molecular imaging |
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| creator | KLETT, Rigobert KORDELLE, Jens STAHL, Ulrich KHALISI, Alexander PUILLE, Maximillian STEINER, Dagmar BAUER, Richard |
| description | Immunoscintigraphy with the use of the antigranulocyte antibody BW 250/183 is a reliable method for detecting infection, especially in septic loosening of hip prostheses, for which purpose quantitative interpretation of the time-activity course is employed. Therefore, we retrospectively studied whether similar results could be achieved in knee prostheses. We verified 28 scintigraphic examinations in 26 patients by histology. Scintigraphy was performed during an early (4-6 h post injection) and a late phase (23-25 h post injection). Infection was diagnosed when activity around the knee prosthesis increased by more than 10% compared with bone marrow. We found a sensitivity and a negative predictive value of 100%, a specificity of 80%, a positive predictive value of 81% and an accuracy of 89%. Specificity and accuracy are lower than in the evaluation of hip prostheses; however, in comparison to other scintigraphic modalities, scintigraphy with the antigranulocyte antibody BW 250/183 is superior in excluding infection and has better specificity and accuracy. Therefore, as in the case of hip prostheses, the described methodology appears to be the scintigraphic modality of choice for knee prostheses. |
| doi_str_mv | 10.1007/s00259-003-1275-1 |
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Therefore, we retrospectively studied whether similar results could be achieved in knee prostheses. We verified 28 scintigraphic examinations in 26 patients by histology. Scintigraphy was performed during an early (4-6 h post injection) and a late phase (23-25 h post injection). Infection was diagnosed when activity around the knee prosthesis increased by more than 10% compared with bone marrow. We found a sensitivity and a negative predictive value of 100%, a specificity of 80%, a positive predictive value of 81% and an accuracy of 89%. Specificity and accuracy are lower than in the evaluation of hip prostheses; however, in comparison to other scintigraphic modalities, scintigraphy with the antigranulocyte antibody BW 250/183 is superior in excluding infection and has better specificity and accuracy. Therefore, as in the case of hip prostheses, the described methodology appears to be the scintigraphic modality of choice for knee prostheses.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-003-1275-1</identifier><identifier>PMID: 14579084</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Aged ; Aged, 80 and over ; Antibodies, Monoclonal ; Biological and medical sciences ; Female ; Granulocytes - diagnostic imaging ; Humans ; Joint Instability - diagnostic imaging ; Joint Instability - etiology ; Joint Instability - pathology ; Knee Joint - diagnostic imaging ; Knee Joint - pathology ; Knee Prosthesis - adverse effects ; Male ; Medical sciences ; Middle Aged ; Prosthesis Failure ; Prosthesis-Related Infections - diagnostic imaging ; Prosthesis-Related Infections - etiology ; Prosthesis-Related Infections - pathology ; Radioimmunodetection - methods ; Radiopharmaceuticals ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Sepsis - diagnostic imaging ; Sepsis - etiology ; Sepsis - pathology ; Technology. Biomaterials. Equipments. Material. 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Therefore, we retrospectively studied whether similar results could be achieved in knee prostheses. We verified 28 scintigraphic examinations in 26 patients by histology. Scintigraphy was performed during an early (4-6 h post injection) and a late phase (23-25 h post injection). Infection was diagnosed when activity around the knee prosthesis increased by more than 10% compared with bone marrow. We found a sensitivity and a negative predictive value of 100%, a specificity of 80%, a positive predictive value of 81% and an accuracy of 89%. Specificity and accuracy are lower than in the evaluation of hip prostheses; however, in comparison to other scintigraphic modalities, scintigraphy with the antigranulocyte antibody BW 250/183 is superior in excluding infection and has better specificity and accuracy. Therefore, as in the case of hip prostheses, the described methodology appears to be the scintigraphic modality of choice for knee prostheses.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Granulocytes - diagnostic imaging</subject><subject>Humans</subject><subject>Joint Instability - diagnostic imaging</subject><subject>Joint Instability - etiology</subject><subject>Joint Instability - pathology</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Knee Joint - pathology</subject><subject>Knee Prosthesis - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prosthesis Failure</subject><subject>Prosthesis-Related Infections - diagnostic imaging</subject><subject>Prosthesis-Related Infections - etiology</subject><subject>Prosthesis-Related Infections - pathology</subject><subject>Radioimmunodetection - methods</subject><subject>Radiopharmaceuticals</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Sepsis - diagnostic imaging</subject><subject>Sepsis - etiology</subject><subject>Sepsis - pathology</subject><subject>Technology. Biomaterials. Equipments. Material. 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Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Sepsis - diagnostic imaging</topic><topic>Sepsis - etiology</topic><topic>Sepsis - pathology</topic><topic>Technology. Biomaterials. Equipments. Material. 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Therefore, we retrospectively studied whether similar results could be achieved in knee prostheses. We verified 28 scintigraphic examinations in 26 patients by histology. Scintigraphy was performed during an early (4-6 h post injection) and a late phase (23-25 h post injection). Infection was diagnosed when activity around the knee prosthesis increased by more than 10% compared with bone marrow. We found a sensitivity and a negative predictive value of 100%, a specificity of 80%, a positive predictive value of 81% and an accuracy of 89%. Specificity and accuracy are lower than in the evaluation of hip prostheses; however, in comparison to other scintigraphic modalities, scintigraphy with the antigranulocyte antibody BW 250/183 is superior in excluding infection and has better specificity and accuracy. Therefore, as in the case of hip prostheses, the described methodology appears to be the scintigraphic modality of choice for knee prostheses.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>14579084</pmid><doi>10.1007/s00259-003-1275-1</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Antibodies, Monoclonal Biological and medical sciences Female Granulocytes - diagnostic imaging Humans Joint Instability - diagnostic imaging Joint Instability - etiology Joint Instability - pathology Knee Joint - diagnostic imaging Knee Joint - pathology Knee Prosthesis - adverse effects Male Medical sciences Middle Aged Prosthesis Failure Prosthesis-Related Infections - diagnostic imaging Prosthesis-Related Infections - etiology Prosthesis-Related Infections - pathology Radioimmunodetection - methods Radiopharmaceuticals Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Reproducibility of Results Retrospective Studies Sensitivity and Specificity Sepsis - diagnostic imaging Sepsis - etiology Sepsis - pathology Technology. Biomaterials. Equipments. Material. Instrumentation |
| title | Immunoscintigraphy of septic loosening of knee endoprosthesis: a retrospective evaluation of the antigranulocyte antibody BW 250/183 |
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