Temporary stretch of the testicular pedicle may damage the vas deferens and the testis
The authors aimed to investigate the effects of temporary stretching of the spermatic cord, a commonly performed manipulation during inguinal surgery, on the vas deferens and the testis. Forty adult male Wistar-Albino rats were divided equally into 4 groups. The right spermatic cord and testis were...
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| Veröffentlicht in: | Journal of pediatric surgery 2003-10, Vol.38 (10), p.1530-1533 |
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| creator | Ceylan, Haluk Karakök, Metin Güldür, Emin Cengiz, Beyhan Bağcı, Cahit Mir, Erol |
| description | The authors aimed to investigate the effects of temporary stretching of the spermatic cord, a commonly performed manipulation during inguinal surgery, on the vas deferens and the testis.
Forty adult male Wistar-Albino rats were divided equally into 4 groups. The right spermatic cord and testis were exposed via a transverse suprascrotal incision. In the study groups, a continuous horizontal stretch force was applied to the vas deferens and vessels in a distal direction for 60 seconds. In group 1 (G1) a 1.25-Newton (N), and in group 2 (G2) a 0.75-N stretch force was applied. Group 3 (G3) and group 4 (G4) served as sham and control groups, respectively. The animals were killed 28 days later. Sections of the vas deferens were examined histologically and their dimensions measured. Both testes were excised, weighed, and examined microscopically. Kruskal-Wallis test and Mann-Whitney U test were used to compare means in the different groups.
The mean wall thickness of the vas deferens was 378 ± 133 μm in G1 and was significantly diminished compared to G2, G3, and G4, in which the mean wall thickness was 497 ± 142 μm, 500 ± 10 μm and 521 ± 95 μm, respectively (
P < .05). The mean right testicular weights were 1.18 ± 0.10 g and 1.23 ± 0.17 g in G1 and G2, respectively, and each was significantly lower than in G3 (1.23 ± 0.09 g) and G4 (1.25 ± 0.08 g;
P < .05). The mean right testicular weights showed no difference between G1 and G2 (
P > .05). Necrosis was seen in the right testes in 50.0% and 42.9% of the animals in G1 and G2, respectively. No histopathologic alterations were observed in the vas deferens in all groups. Microscopic examination of the left testes was normal.
In an experimental animal model, temporary stretching of the spermatic cord resulted in significant thinning of the smooth muscle layer of the vas deferens and testicular atrophy. |
| doi_str_mv | 10.1016/S0022-3468(03)00508-6 |
| format | Article |
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Forty adult male Wistar-Albino rats were divided equally into 4 groups. The right spermatic cord and testis were exposed via a transverse suprascrotal incision. In the study groups, a continuous horizontal stretch force was applied to the vas deferens and vessels in a distal direction for 60 seconds. In group 1 (G1) a 1.25-Newton (N), and in group 2 (G2) a 0.75-N stretch force was applied. Group 3 (G3) and group 4 (G4) served as sham and control groups, respectively. The animals were killed 28 days later. Sections of the vas deferens were examined histologically and their dimensions measured. Both testes were excised, weighed, and examined microscopically. Kruskal-Wallis test and Mann-Whitney U test were used to compare means in the different groups.
The mean wall thickness of the vas deferens was 378 ± 133 μm in G1 and was significantly diminished compared to G2, G3, and G4, in which the mean wall thickness was 497 ± 142 μm, 500 ± 10 μm and 521 ± 95 μm, respectively (
P < .05). The mean right testicular weights were 1.18 ± 0.10 g and 1.23 ± 0.17 g in G1 and G2, respectively, and each was significantly lower than in G3 (1.23 ± 0.09 g) and G4 (1.25 ± 0.08 g;
P < .05). The mean right testicular weights showed no difference between G1 and G2 (
P > .05). Necrosis was seen in the right testes in 50.0% and 42.9% of the animals in G1 and G2, respectively. No histopathologic alterations were observed in the vas deferens in all groups. Microscopic examination of the left testes was normal.
In an experimental animal model, temporary stretching of the spermatic cord resulted in significant thinning of the smooth muscle layer of the vas deferens and testicular atrophy.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/S0022-3468(03)00508-6</identifier><identifier>PMID: 14577081</identifier><identifier>CODEN: JPDSA3</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; General aspects ; Genitalia, Male - surgery ; Gynecology. Andrology. Obstetrics ; Inguinal hernia repair ; Intraoperative Complications - etiology ; Male ; Male genital diseases ; Medical sciences ; Muscle, Smooth - pathology ; Necrosis ; Non tumoral diseases ; Organ Size ; Rats ; Rats, Wistar ; Spermatic Cord - physiopathology ; Stress, Mechanical ; stretch injury ; testis ; Testis - injuries ; Testis - pathology ; Urogenital Surgical Procedures - adverse effects ; vas deferens ; Vas Deferens - injuries ; Vas Deferens - pathology</subject><ispartof>Journal of pediatric surgery, 2003-10, Vol.38 (10), p.1530-1533</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-fef589fccc980842831e0afead6297434f45951f0a4ef2462e5e1a22e0ab88d3</citedby><cites>FETCH-LOGICAL-c457t-fef589fccc980842831e0afead6297434f45951f0a4ef2462e5e1a22e0ab88d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3468(03)00508-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3548,23928,23929,25138,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15201032$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14577081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ceylan, Haluk</creatorcontrib><creatorcontrib>Karakök, Metin</creatorcontrib><creatorcontrib>Güldür, Emin</creatorcontrib><creatorcontrib>Cengiz, Beyhan</creatorcontrib><creatorcontrib>Bağcı, Cahit</creatorcontrib><creatorcontrib>Mir, Erol</creatorcontrib><title>Temporary stretch of the testicular pedicle may damage the vas deferens and the testis</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>The authors aimed to investigate the effects of temporary stretching of the spermatic cord, a commonly performed manipulation during inguinal surgery, on the vas deferens and the testis.
Forty adult male Wistar-Albino rats were divided equally into 4 groups. The right spermatic cord and testis were exposed via a transverse suprascrotal incision. In the study groups, a continuous horizontal stretch force was applied to the vas deferens and vessels in a distal direction for 60 seconds. In group 1 (G1) a 1.25-Newton (N), and in group 2 (G2) a 0.75-N stretch force was applied. Group 3 (G3) and group 4 (G4) served as sham and control groups, respectively. The animals were killed 28 days later. Sections of the vas deferens were examined histologically and their dimensions measured. Both testes were excised, weighed, and examined microscopically. Kruskal-Wallis test and Mann-Whitney U test were used to compare means in the different groups.
The mean wall thickness of the vas deferens was 378 ± 133 μm in G1 and was significantly diminished compared to G2, G3, and G4, in which the mean wall thickness was 497 ± 142 μm, 500 ± 10 μm and 521 ± 95 μm, respectively (
P < .05). The mean right testicular weights were 1.18 ± 0.10 g and 1.23 ± 0.17 g in G1 and G2, respectively, and each was significantly lower than in G3 (1.23 ± 0.09 g) and G4 (1.25 ± 0.08 g;
P < .05). The mean right testicular weights showed no difference between G1 and G2 (
P > .05). Necrosis was seen in the right testes in 50.0% and 42.9% of the animals in G1 and G2, respectively. No histopathologic alterations were observed in the vas deferens in all groups. Microscopic examination of the left testes was normal.
In an experimental animal model, temporary stretching of the spermatic cord resulted in significant thinning of the smooth muscle layer of the vas deferens and testicular atrophy.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>General aspects</subject><subject>Genitalia, Male - surgery</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Inguinal hernia repair</subject><subject>Intraoperative Complications - etiology</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Muscle, Smooth - pathology</subject><subject>Necrosis</subject><subject>Non tumoral diseases</subject><subject>Organ Size</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spermatic Cord - physiopathology</subject><subject>Stress, Mechanical</subject><subject>stretch injury</subject><subject>testis</subject><subject>Testis - injuries</subject><subject>Testis - pathology</subject><subject>Urogenital Surgical Procedures - adverse effects</subject><subject>vas deferens</subject><subject>Vas Deferens - injuries</subject><subject>Vas Deferens - pathology</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMoWi-PoGSj6GL05DaTrkSKNyi4sLgNMXOiI3OpyUyhb29si126OnD4_vwnHyGnDK4ZsPzmFYDzTMhcX4K4AlCgs3yHjJgSLFMgil0y-kMOyGGMXwBpDWyfHDCpigI0G5G3GTbzLtiwpLEP2LtP2nnafyLtMfaVG2ob6BzLytVIG7ukpW3sB66IhY20RI8B20htW25j8ZjseVtHPNnMIzJ7uJ9NnrLpy-Pz5G6auXRBn3n0So-9c26sQUuuBUOwHm2Z83EhhfRSjRXzYCV6LnOOCpnlPEHvWpfiiFysn52H7ntIzaaposO6ti12QzQFE6A4yASqNehCF2NAb-ahatKvDQPz69OsfJpfWQaEWfk0ecqdbQqG9wbLbWojMAHnG8BGZ2sfbOuquOVSOwPBE3e75jDZWFQYTHQVti6ZDeh6U3bVP6f8ALTwkfA</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Ceylan, Haluk</creator><creator>Karakök, Metin</creator><creator>Güldür, Emin</creator><creator>Cengiz, Beyhan</creator><creator>Bağcı, Cahit</creator><creator>Mir, Erol</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Temporary stretch of the testicular pedicle may damage the vas deferens and the testis</title><author>Ceylan, Haluk ; Karakök, Metin ; Güldür, Emin ; Cengiz, Beyhan ; Bağcı, Cahit ; Mir, Erol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-fef589fccc980842831e0afead6297434f45951f0a4ef2462e5e1a22e0ab88d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>General aspects</topic><topic>Genitalia, Male - surgery</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Inguinal hernia repair</topic><topic>Intraoperative Complications - etiology</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Muscle, Smooth - pathology</topic><topic>Necrosis</topic><topic>Non tumoral diseases</topic><topic>Organ Size</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spermatic Cord - physiopathology</topic><topic>Stress, Mechanical</topic><topic>stretch injury</topic><topic>testis</topic><topic>Testis - injuries</topic><topic>Testis - pathology</topic><topic>Urogenital Surgical Procedures - adverse effects</topic><topic>vas deferens</topic><topic>Vas Deferens - injuries</topic><topic>Vas Deferens - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ceylan, Haluk</creatorcontrib><creatorcontrib>Karakök, Metin</creatorcontrib><creatorcontrib>Güldür, Emin</creatorcontrib><creatorcontrib>Cengiz, Beyhan</creatorcontrib><creatorcontrib>Bağcı, Cahit</creatorcontrib><creatorcontrib>Mir, Erol</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ceylan, Haluk</au><au>Karakök, Metin</au><au>Güldür, Emin</au><au>Cengiz, Beyhan</au><au>Bağcı, Cahit</au><au>Mir, Erol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporary stretch of the testicular pedicle may damage the vas deferens and the testis</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>38</volume><issue>10</issue><spage>1530</spage><epage>1533</epage><pages>1530-1533</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><coden>JPDSA3</coden><abstract>The authors aimed to investigate the effects of temporary stretching of the spermatic cord, a commonly performed manipulation during inguinal surgery, on the vas deferens and the testis.
Forty adult male Wistar-Albino rats were divided equally into 4 groups. The right spermatic cord and testis were exposed via a transverse suprascrotal incision. In the study groups, a continuous horizontal stretch force was applied to the vas deferens and vessels in a distal direction for 60 seconds. In group 1 (G1) a 1.25-Newton (N), and in group 2 (G2) a 0.75-N stretch force was applied. Group 3 (G3) and group 4 (G4) served as sham and control groups, respectively. The animals were killed 28 days later. Sections of the vas deferens were examined histologically and their dimensions measured. Both testes were excised, weighed, and examined microscopically. Kruskal-Wallis test and Mann-Whitney U test were used to compare means in the different groups.
The mean wall thickness of the vas deferens was 378 ± 133 μm in G1 and was significantly diminished compared to G2, G3, and G4, in which the mean wall thickness was 497 ± 142 μm, 500 ± 10 μm and 521 ± 95 μm, respectively (
P < .05). The mean right testicular weights were 1.18 ± 0.10 g and 1.23 ± 0.17 g in G1 and G2, respectively, and each was significantly lower than in G3 (1.23 ± 0.09 g) and G4 (1.25 ± 0.08 g;
P < .05). The mean right testicular weights showed no difference between G1 and G2 (
P > .05). Necrosis was seen in the right testes in 50.0% and 42.9% of the animals in G1 and G2, respectively. No histopathologic alterations were observed in the vas deferens in all groups. Microscopic examination of the left testes was normal.
In an experimental animal model, temporary stretching of the spermatic cord resulted in significant thinning of the smooth muscle layer of the vas deferens and testicular atrophy.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>14577081</pmid><doi>10.1016/S0022-3468(03)00508-6</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences General aspects Genitalia, Male - surgery Gynecology. Andrology. Obstetrics Inguinal hernia repair Intraoperative Complications - etiology Male Male genital diseases Medical sciences Muscle, Smooth - pathology Necrosis Non tumoral diseases Organ Size Rats Rats, Wistar Spermatic Cord - physiopathology Stress, Mechanical stretch injury testis Testis - injuries Testis - pathology Urogenital Surgical Procedures - adverse effects vas deferens Vas Deferens - injuries Vas Deferens - pathology |
| title | Temporary stretch of the testicular pedicle may damage the vas deferens and the testis |
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