Protein S Deficiency Presenting as Deep Vein Thrombosis: A Case Report
A rare case of spontaneous bilateral internal jugular vein (IJV) thrombosis is presented in absence of oral infection, malignancy, or intervention. Swelling of face, neck, and both upper limbs developed in a 30-year-old man 1 month before admission and after 4 weeks of use of nonpadded crutches. Com...
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| Veröffentlicht in: | Angiology 2003-09, Vol.54 (5), p.605-608 |
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| creator | Khandekar, Ashwinikumar A. Kumbhalkar, Sunita D. Salkar, Harsha R. Parakkadavathu, Rakesh T. Salkar, Ramesh G. |
| description | A rare case of spontaneous bilateral internal jugular vein (IJV) thrombosis is presented in absence of oral infection, malignancy, or intervention. Swelling of face, neck, and both upper limbs developed in a 30-year-old man 1 month before admission and after 4 weeks of use of nonpadded crutches. Computed tomography of the neck showed thrombus occluding both internal jugular veins extending to the opening of the superior vena cava. Protein S activity was found to be 30.3%, less than half of the lower limit of normal. Fibrinogen was 450 mg%, higher than normal. Protein C and antithrombin III were normal. The patient was treated conserva tively, and discharged on aspirin 150 mg/day. Follow-up after 3 months showed no complica tions. It was concluded that the outcome in IJV thrombosis, caused by protein S deficiency, is usually good. The advantage of being aware of diagnosis is that physician can be more vigilant for potential complications and treat them earlier. |
| doi_str_mv | 10.1177/000331970305400511 |
| format | Article |
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Swelling of face, neck, and both upper limbs developed in a 30-year-old man 1 month before admission and after 4 weeks of use of nonpadded crutches. Computed tomography of the neck showed thrombus occluding both internal jugular veins extending to the opening of the superior vena cava. Protein S activity was found to be 30.3%, less than half of the lower limit of normal. Fibrinogen was 450 mg%, higher than normal. Protein C and antithrombin III were normal. The patient was treated conserva tively, and discharged on aspirin 150 mg/day. Follow-up after 3 months showed no complica tions. It was concluded that the outcome in IJV thrombosis, caused by protein S deficiency, is usually good. The advantage of being aware of diagnosis is that physician can be more vigilant for potential complications and treat them earlier.</description><identifier>ISSN: 0003-3197</identifier><identifier>EISSN: 1940-1574</identifier><identifier>DOI: 10.1177/000331970305400511</identifier><identifier>PMID: 14565637</identifier><identifier>CODEN: ANGIAB</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adult ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood clot ; Cardiology. Vascular system ; Case studies ; Diagnosis ; Diseases ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Humans ; Jugular Veins ; Male ; Medical sciences ; Protein S deficiency ; Protein S Deficiency - complications ; Protein S Deficiency - diagnosis ; Thrombosis ; Veins ; Venous thrombosis ; Venous Thrombosis - etiology</subject><ispartof>Angiology, 2003-09, Vol.54 (5), p.605-608</ispartof><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2003 Sage Publications, Inc.</rights><rights>Copyright Westminster Publications, Inc. 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Swelling of face, neck, and both upper limbs developed in a 30-year-old man 1 month before admission and after 4 weeks of use of nonpadded crutches. Computed tomography of the neck showed thrombus occluding both internal jugular veins extending to the opening of the superior vena cava. Protein S activity was found to be 30.3%, less than half of the lower limit of normal. Fibrinogen was 450 mg%, higher than normal. Protein C and antithrombin III were normal. The patient was treated conserva tively, and discharged on aspirin 150 mg/day. Follow-up after 3 months showed no complica tions. It was concluded that the outcome in IJV thrombosis, caused by protein S deficiency, is usually good. The advantage of being aware of diagnosis is that physician can be more vigilant for potential complications and treat them earlier.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood clot</subject><subject>Cardiology. Vascular system</subject><subject>Case studies</subject><subject>Diagnosis</subject><subject>Diseases</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Humans</subject><subject>Jugular Veins</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Protein S deficiency</subject><subject>Protein S Deficiency - complications</subject><subject>Protein S Deficiency - diagnosis</subject><subject>Thrombosis</subject><subject>Veins</subject><subject>Venous thrombosis</subject><subject>Venous Thrombosis - etiology</subject><issn>0003-3197</issn><issn>1940-1574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90V1rFDEUBuAgil2rf8ALGQS9mzbfmVyW-gkFC1Zvh8yZkzVlJlmT2Yv-ezPswoIWyUUged7kJIeQ14xeMGbMJaVUCGYNFVRJShVjT8iGWUlbpox8SjYraFdxRl6Uck9XQ_Vzcsak0koLsyHmNqcFQ2y-Nx_QBwgY4aG5zVgwLiFuG1fqBu6anyu6-5XTPKQSykvyzLup4KvjfE5-fPp4d_2lvfn2-ev11U0LksulHSQiDkaClQBcGwbaStHRAQGEHQX3ox8oMDuCws56o203GE4FoJXSc3FO3h_O3eX0e49l6edQAKfJRUz70hsmqFBUVvj2L3if9jnW2nrOpbbCMFVRe0BbN2Efok9LdrDFiNlNKdYPqMtXjHZWdzVU_cUjvo4R5wCPBvghADmVktH3uxxmlx96Rvu1af2_TauhN8fS98OM4yly7FIF747AFXCTzy5CKCenmJZci-ouD664LZ7e_5-r_wBwoai6</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Khandekar, Ashwinikumar A.</creator><creator>Kumbhalkar, Sunita D.</creator><creator>Salkar, Harsha R.</creator><creator>Parakkadavathu, Rakesh T.</creator><creator>Salkar, Ramesh G.</creator><general>SAGE Publications</general><general>Westminster</general><general>Sage Publications, Inc</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Protein S Deficiency Presenting as Deep Vein Thrombosis</title><author>Khandekar, Ashwinikumar A. ; Kumbhalkar, Sunita D. ; Salkar, Harsha R. ; Parakkadavathu, Rakesh T. ; Salkar, Ramesh G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-b4eeeb74c94cc2671c694380becc39d32fdfb0c19dc5e89f7698b7203ce944f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood clot</topic><topic>Cardiology. Vascular system</topic><topic>Case studies</topic><topic>Diagnosis</topic><topic>Diseases</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Humans</topic><topic>Jugular Veins</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Protein S deficiency</topic><topic>Protein S Deficiency - complications</topic><topic>Protein S Deficiency - diagnosis</topic><topic>Thrombosis</topic><topic>Veins</topic><topic>Venous thrombosis</topic><topic>Venous Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khandekar, Ashwinikumar A.</creatorcontrib><creatorcontrib>Kumbhalkar, Sunita D.</creatorcontrib><creatorcontrib>Salkar, Harsha R.</creatorcontrib><creatorcontrib>Parakkadavathu, Rakesh T.</creatorcontrib><creatorcontrib>Salkar, Ramesh G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Angiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khandekar, Ashwinikumar A.</au><au>Kumbhalkar, Sunita D.</au><au>Salkar, Harsha R.</au><au>Parakkadavathu, Rakesh T.</au><au>Salkar, Ramesh G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein S Deficiency Presenting as Deep Vein Thrombosis: A Case Report</atitle><jtitle>Angiology</jtitle><addtitle>Angiology</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>54</volume><issue>5</issue><spage>605</spage><epage>608</epage><pages>605-608</pages><issn>0003-3197</issn><eissn>1940-1574</eissn><coden>ANGIAB</coden><abstract>A rare case of spontaneous bilateral internal jugular vein (IJV) thrombosis is presented in absence of oral infection, malignancy, or intervention. Swelling of face, neck, and both upper limbs developed in a 30-year-old man 1 month before admission and after 4 weeks of use of nonpadded crutches. Computed tomography of the neck showed thrombus occluding both internal jugular veins extending to the opening of the superior vena cava. Protein S activity was found to be 30.3%, less than half of the lower limit of normal. Fibrinogen was 450 mg%, higher than normal. Protein C and antithrombin III were normal. The patient was treated conserva tively, and discharged on aspirin 150 mg/day. Follow-up after 3 months showed no complica tions. It was concluded that the outcome in IJV thrombosis, caused by protein S deficiency, is usually good. The advantage of being aware of diagnosis is that physician can be more vigilant for potential complications and treat them earlier.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>14565637</pmid><doi>10.1177/000331970305400511</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Blood and lymphatic vessels Blood clot Cardiology. Vascular system Case studies Diagnosis Diseases Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Humans Jugular Veins Male Medical sciences Protein S deficiency Protein S Deficiency - complications Protein S Deficiency - diagnosis Thrombosis Veins Venous thrombosis Venous Thrombosis - etiology |
| title | Protein S Deficiency Presenting as Deep Vein Thrombosis: A Case Report |
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