Influence of anticoagulants on the measurement of S100B protein in blood
Evaluate anticoagulants influence on plasma S100B levels. Blood were collected from 18 healthy adult subjects using: no anticoagulants, EDTA, heparin, and citrate. S100B levels were determined using LIA-mat assay. Heparin plasma and citrate increased plasma S100B levels ( p < 0.001), whereas EDTA...
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| Veröffentlicht in: | Clinical biochemistry 2003-10, Vol.36 (7), p.519-522 |
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| creator | Tort, Adriano B.L Dietrich, Marcelo O Gonçalves, Carlos A Souza, Diogo O Portela, Luis V.C |
| description | Evaluate anticoagulants influence on plasma S100B levels.
Blood were collected from 18 healthy adult subjects using: no anticoagulants, EDTA, heparin, and citrate. S100B levels were determined using LIA-mat assay.
Heparin plasma and citrate increased plasma S100B levels (
p < 0.001), whereas EDTA had no effect (
p = 0.24). Heparin plasma samples were highly (r
2 = 0.97,
p < 0.001), citrate samples were moderately (r
2 = 0.49,
p < 0.001), and EDTA samples were not (r
2 = 0.22,
p = 0.059) correlated with serum samples.
When anticoagulant is required, heparin plasma should be the primary choice for measurement of S100 B levels. |
| doi_str_mv | 10.1016/S0009-9120(03)00104-8 |
| format | Article |
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Blood were collected from 18 healthy adult subjects using: no anticoagulants, EDTA, heparin, and citrate. S100B levels were determined using LIA-mat assay.
Heparin plasma and citrate increased plasma S100B levels (
p < 0.001), whereas EDTA had no effect (
p = 0.24). Heparin plasma samples were highly (r
2 = 0.97,
p < 0.001), citrate samples were moderately (r
2 = 0.49,
p < 0.001), and EDTA samples were not (r
2 = 0.22,
p = 0.059) correlated with serum samples.
When anticoagulant is required, heparin plasma should be the primary choice for measurement of S100 B levels.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/S0009-9120(03)00104-8</identifier><identifier>PMID: 14563444</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Anticoagulants ; Anticoagulants - pharmacology ; Blood ; Citric Acid ; Edetic Acid ; Female ; Heparin ; Humans ; Immunoluminometric assay ; Male ; S100 Proteins - blood ; S100B</subject><ispartof>Clinical biochemistry, 2003-10, Vol.36 (7), p.519-522</ispartof><rights>2003 The Canadian Society of Clinical Chemists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-700eeccfbce955ac699b4417dfb592a9e7464ac822c261bdc3213203641b0b1b3</citedby><cites>FETCH-LOGICAL-c361t-700eeccfbce955ac699b4417dfb592a9e7464ac822c261bdc3213203641b0b1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0009-9120(03)00104-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14563444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tort, Adriano B.L</creatorcontrib><creatorcontrib>Dietrich, Marcelo O</creatorcontrib><creatorcontrib>Gonçalves, Carlos A</creatorcontrib><creatorcontrib>Souza, Diogo O</creatorcontrib><creatorcontrib>Portela, Luis V.C</creatorcontrib><title>Influence of anticoagulants on the measurement of S100B protein in blood</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>Evaluate anticoagulants influence on plasma S100B levels.
Blood were collected from 18 healthy adult subjects using: no anticoagulants, EDTA, heparin, and citrate. S100B levels were determined using LIA-mat assay.
Heparin plasma and citrate increased plasma S100B levels (
p < 0.001), whereas EDTA had no effect (
p = 0.24). Heparin plasma samples were highly (r
2 = 0.97,
p < 0.001), citrate samples were moderately (r
2 = 0.49,
p < 0.001), and EDTA samples were not (r
2 = 0.22,
p = 0.059) correlated with serum samples.
When anticoagulant is required, heparin plasma should be the primary choice for measurement of S100 B levels.</description><subject>Adult</subject><subject>Anticoagulants</subject><subject>Anticoagulants - pharmacology</subject><subject>Blood</subject><subject>Citric Acid</subject><subject>Edetic Acid</subject><subject>Female</subject><subject>Heparin</subject><subject>Humans</subject><subject>Immunoluminometric assay</subject><subject>Male</subject><subject>S100 Proteins - blood</subject><subject>S100B</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMo7vr4CUpPoofqTJI-chJdfMGCh9VzaNKpVtpmbVrBf2_2gR6FgZnAN498jJ0gXCJgerUAABUr5HAO4gIAQcb5DptinomYKyF22fQXmbAD7z_Ck8s83WcTlEkqpJRT9vjUVc1InaXIVVHRDbV1xdvYhMpHrouGd4paKvzYU0vdsIIWCHAbLXs3UN1FIUzjXHnE9qqi8XS8zYfs9f7uZfYYz58fnmY389iKFIc4AyCytjKWVJIUNlXKSIlZWZlE8UJRJlNZ2Jxzy1M0pRUcBQeRSjRg0IhDdraZGw74HMkPuq29pSZcTG70OkMBApUKYLIBbe-876nSy75ui_5bI-iVQr1WqFd-NAi9Vqjz0He6XTCalsq_rq2zAFxvAArf_Kqp197WK4Nl3ZMddOnqf1b8AKddf1s</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Tort, Adriano B.L</creator><creator>Dietrich, Marcelo O</creator><creator>Gonçalves, Carlos A</creator><creator>Souza, Diogo O</creator><creator>Portela, Luis V.C</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Influence of anticoagulants on the measurement of S100B protein in blood</title><author>Tort, Adriano B.L ; Dietrich, Marcelo O ; Gonçalves, Carlos A ; Souza, Diogo O ; Portela, Luis V.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-700eeccfbce955ac699b4417dfb592a9e7464ac822c261bdc3213203641b0b1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Anticoagulants</topic><topic>Anticoagulants - pharmacology</topic><topic>Blood</topic><topic>Citric Acid</topic><topic>Edetic Acid</topic><topic>Female</topic><topic>Heparin</topic><topic>Humans</topic><topic>Immunoluminometric assay</topic><topic>Male</topic><topic>S100 Proteins - blood</topic><topic>S100B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tort, Adriano B.L</creatorcontrib><creatorcontrib>Dietrich, Marcelo O</creatorcontrib><creatorcontrib>Gonçalves, Carlos A</creatorcontrib><creatorcontrib>Souza, Diogo O</creatorcontrib><creatorcontrib>Portela, Luis V.C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tort, Adriano B.L</au><au>Dietrich, Marcelo O</au><au>Gonçalves, Carlos A</au><au>Souza, Diogo O</au><au>Portela, Luis V.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of anticoagulants on the measurement of S100B protein in blood</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>36</volume><issue>7</issue><spage>519</spage><epage>522</epage><pages>519-522</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Evaluate anticoagulants influence on plasma S100B levels.
Blood were collected from 18 healthy adult subjects using: no anticoagulants, EDTA, heparin, and citrate. S100B levels were determined using LIA-mat assay.
Heparin plasma and citrate increased plasma S100B levels (
p < 0.001), whereas EDTA had no effect (
p = 0.24). Heparin plasma samples were highly (r
2 = 0.97,
p < 0.001), citrate samples were moderately (r
2 = 0.49,
p < 0.001), and EDTA samples were not (r
2 = 0.22,
p = 0.059) correlated with serum samples.
When anticoagulant is required, heparin plasma should be the primary choice for measurement of S100 B levels.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>14563444</pmid><doi>10.1016/S0009-9120(03)00104-8</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9120 |
| ispartof | Clinical biochemistry, 2003-10, Vol.36 (7), p.519-522 |
| issn | 0009-9120 1873-2933 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71303199 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Anticoagulants Anticoagulants - pharmacology Blood Citric Acid Edetic Acid Female Heparin Humans Immunoluminometric assay Male S100 Proteins - blood S100B |
| title | Influence of anticoagulants on the measurement of S100B protein in blood |
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