Specific HIV-1 env gene silencing by small interfering RNAs in human peripheral blood mononuclear cells

RNA interference (RNAi) is triggered by the presence of a double-stranded RNA (dsRNA) in the cell, and results in the silencing of homologous gene expression by the specific degradation of an mRNA containing the same sequence. dsRNA-mediated RNAi can be used in a wide variety of eucaryotes to induce...

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Veröffentlicht in:	Gene therapy 2003-11, Vol.10 (24), p.2046-2050
Hauptverfasser:	Park, W-S, Hayafune, M, Miyano-Kurosaki, N, Takaku, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antisense RNA Antiviral agents Applied cell therapy and gene therapy Base Sequence Binding sites Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology brief-communication Care and treatment CD4 antigen Cell Biology Cells, Cultured COS Cells Double-stranded RNA Env gene Env protein Fundamental and applied biological sciences. Psychology Gene Expression Gene Silencing Gene Therapy Genes, env - genetics Genetic aspects Genetic Therapy - methods Glycoprotein gp120 Health aspects Health. Pharmaceutical industry HIV HIV infection HIV-1 - genetics HIV-1 - physiology Human Genetics Human immunodeficiency virus Humans Industrial applications and implications. Economical aspects Kinases Leukocytes (mononuclear) Leukocytes, Mononuclear - virology Mammalian cells Medical sciences Methods Molecular Sequence Data Nanotechnology Peripheral blood mononuclear cells Physiological aspects RNA Interference RNA, Messenger - genetics RNA, Small Interfering - genetics RNA, Viral - genetics RNA-mediated interference siRNA Transfusions. Complications. Transfusion reactions. Cell and gene therapy Virus Replication
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