In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction

Heparan, the common unsulfated precursor of heparan sulfate (HS) and heparin, is synthesized on the glycosaminoglycan-protein linkage region tetrasaccharide GlcUA-Gal-Gal-Xyl attached to the respective core proteins presumably by HS co-polymerases encoded by EXT1 and EXT2, the genetic defects of whi...

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Veröffentlicht in:	The Journal of biological chemistry 2003-10, Vol.278 (43), p.41618-41623
Hauptverfasser:	Kim, Byung-Taek, Kitagawa, Hiroshi, Tanaka, Junko, Tamura, Jun-ichi, Sugahara, Kazuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	a-thrombomodulin Animals COS Cells exostoses EXT1 protein EXT2 protein heparan sulfate Heparan Sulfate Proteoglycans - genetics Heparan Sulfate Proteoglycans - metabolism Heparitin Sulfate - biosynthesis Humans N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism Oligosaccharides Substrate Specificity Thrombomodulin - metabolism Transfection Uridine Diphosphate Sugars - metabolism
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