T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK
Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal tra...
Gespeichert in:
| Veröffentlicht in: | FEBS letters 2003-10, Vol.553 (3), p.403-407 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 407 |
|---|---|
| container_issue | 3 |
| container_start_page | 403 |
| container_title | FEBS letters |
| container_volume | 553 |
| creator | Dadgostar, Hajir Doyle, Sean E. Shahangian, Arash Garcia, Daniel E. Cheng, Genhong |
| description | Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator). This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent-insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-κB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation. |
| doi_str_mv | 10.1016/S0014-5793(03)01072-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_71300302</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S001457930301072X</els_id><sourcerecordid>71300302</sourcerecordid><originalsourceid>FETCH-LOGICAL-c315t-65e44faf74463df58dd30bd0c08a68e5ffe2492d8d9a663af9e9c1475576d2393</originalsourceid><addsrcrecordid>eNo9kVtLAzEQhYMoWqs_QcmTKLiabC67-ySleKs30Aq-xZhMaGS7Wzdppf_e1BsMDAPfGQ7nILRHyQklVJ4-EUJ5JoqKHRJ2RCgp8uxlDfVoWbCMcVmuo94_soW2Q3gn6S5ptYm2KBdFLkXVQ69jNhrcHWONm3YBNZ51bQTf4DjREYcZGO-80XW9xL6J0GkTA_70cYLHj4MLhnVjV5JpEoWkAZwAv9DRtw1uHR7d3-ygDafrALu_u4-eL87Hw6vs9uHyeji4zQyjImZSAOdOu4JzyawTpbWMvFliSKllCcI5yHmV29JWWkqmXQWVobwQopA2ZxXro4Ofv8nOxxxCVFMfDNS1bqCdB1VQRggjeQL3f8H52xSsmnV-qrul-sskAWc_ACS7Cw-dCsZDY8D6DkxUtvWKErVqQX23oFYRK5Jm1YJ6YV_NgHfd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71300302</pqid></control><display><type>article</type><title>T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elsevier ScienceDirect Journals</source><source>Wiley Online Library Free Content</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Dadgostar, Hajir ; Doyle, Sean E. ; Shahangian, Arash ; Garcia, Daniel E. ; Cheng, Genhong</creator><creatorcontrib>Dadgostar, Hajir ; Doyle, Sean E. ; Shahangian, Arash ; Garcia, Daniel E. ; Cheng, Genhong</creatorcontrib><description>Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator). This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent-insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-κB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(03)01072-X</identifier><identifier>PMID: 14572659</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Cell Line ; Enzyme Activation ; Humans ; JNK Mitogen-Activated Protein Kinases ; Jun N-terminal kinase ; Mice ; Mice, Inbred C57BL ; Microtubule-Associated Proteins - metabolism ; Mitogen-Activated Protein Kinases - metabolism ; Molecular Sequence Data ; Nuclear factor κB ; Organ Specificity ; Protein Structure, Tertiary ; Proteins - metabolism ; Receptors, Tumor Necrosis Factor - metabolism ; Sequence Homology, Amino Acid ; Signal Transduction ; Subcellular Fractions - metabolism ; Subcellular localization ; Substrate Specificity ; TNF Receptor-Associated Factor 3 ; Transfection ; Tumor necrosis factor receptor ; Tumor necrosis factor receptor-associated factor 3 ; Two-Hybrid System Techniques</subject><ispartof>FEBS letters, 2003-10, Vol.553 (3), p.403-407</ispartof><rights>2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-65e44faf74463df58dd30bd0c08a68e5ffe2492d8d9a663af9e9c1475576d2393</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S001457930301072X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14572659$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dadgostar, Hajir</creatorcontrib><creatorcontrib>Doyle, Sean E.</creatorcontrib><creatorcontrib>Shahangian, Arash</creatorcontrib><creatorcontrib>Garcia, Daniel E.</creatorcontrib><creatorcontrib>Cheng, Genhong</creatorcontrib><title>T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator). This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent-insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-κB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Cell Line</subject><subject>Enzyme Activation</subject><subject>Humans</subject><subject>JNK Mitogen-Activated Protein Kinases</subject><subject>Jun N-terminal kinase</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Nuclear factor κB</subject><subject>Organ Specificity</subject><subject>Protein Structure, Tertiary</subject><subject>Proteins - metabolism</subject><subject>Receptors, Tumor Necrosis Factor - metabolism</subject><subject>Sequence Homology, Amino Acid</subject><subject>Signal Transduction</subject><subject>Subcellular Fractions - metabolism</subject><subject>Subcellular localization</subject><subject>Substrate Specificity</subject><subject>TNF Receptor-Associated Factor 3</subject><subject>Transfection</subject><subject>Tumor necrosis factor receptor</subject><subject>Tumor necrosis factor receptor-associated factor 3</subject><subject>Two-Hybrid System Techniques</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kVtLAzEQhYMoWqs_QcmTKLiabC67-ySleKs30Aq-xZhMaGS7Wzdppf_e1BsMDAPfGQ7nILRHyQklVJ4-EUJ5JoqKHRJ2RCgp8uxlDfVoWbCMcVmuo94_soW2Q3gn6S5ptYm2KBdFLkXVQ69jNhrcHWONm3YBNZ51bQTf4DjREYcZGO-80XW9xL6J0GkTA_70cYLHj4MLhnVjV5JpEoWkAZwAv9DRtw1uHR7d3-ygDafrALu_u4-eL87Hw6vs9uHyeji4zQyjImZSAOdOu4JzyawTpbWMvFliSKllCcI5yHmV29JWWkqmXQWVobwQopA2ZxXro4Ofv8nOxxxCVFMfDNS1bqCdB1VQRggjeQL3f8H52xSsmnV-qrul-sskAWc_ACS7Cw-dCsZDY8D6DkxUtvWKErVqQX23oFYRK5Jm1YJ6YV_NgHfd</recordid><startdate>20031023</startdate><enddate>20031023</enddate><creator>Dadgostar, Hajir</creator><creator>Doyle, Sean E.</creator><creator>Shahangian, Arash</creator><creator>Garcia, Daniel E.</creator><creator>Cheng, Genhong</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20031023</creationdate><title>T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK</title><author>Dadgostar, Hajir ; Doyle, Sean E. ; Shahangian, Arash ; Garcia, Daniel E. ; Cheng, Genhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-65e44faf74463df58dd30bd0c08a68e5ffe2492d8d9a663af9e9c1475576d2393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Cell Line</topic><topic>Enzyme Activation</topic><topic>Humans</topic><topic>JNK Mitogen-Activated Protein Kinases</topic><topic>Jun N-terminal kinase</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Nuclear factor κB</topic><topic>Organ Specificity</topic><topic>Protein Structure, Tertiary</topic><topic>Proteins - metabolism</topic><topic>Receptors, Tumor Necrosis Factor - metabolism</topic><topic>Sequence Homology, Amino Acid</topic><topic>Signal Transduction</topic><topic>Subcellular Fractions - metabolism</topic><topic>Subcellular localization</topic><topic>Substrate Specificity</topic><topic>TNF Receptor-Associated Factor 3</topic><topic>Transfection</topic><topic>Tumor necrosis factor receptor</topic><topic>Tumor necrosis factor receptor-associated factor 3</topic><topic>Two-Hybrid System Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dadgostar, Hajir</creatorcontrib><creatorcontrib>Doyle, Sean E.</creatorcontrib><creatorcontrib>Shahangian, Arash</creatorcontrib><creatorcontrib>Garcia, Daniel E.</creatorcontrib><creatorcontrib>Cheng, Genhong</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dadgostar, Hajir</au><au>Doyle, Sean E.</au><au>Shahangian, Arash</au><au>Garcia, Daniel E.</au><au>Cheng, Genhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2003-10-23</date><risdate>2003</risdate><volume>553</volume><issue>3</issue><spage>403</spage><epage>407</epage><pages>403-407</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator). This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent-insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-κB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>14572659</pmid><doi>10.1016/S0014-5793(03)01072-X</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 2003-10, Vol.553 (3), p.403-407 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71300302 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Wiley Online Library Free Content; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Amino Acid Sequence Animals Cell Line Enzyme Activation Humans JNK Mitogen-Activated Protein Kinases Jun N-terminal kinase Mice Mice, Inbred C57BL Microtubule-Associated Proteins - metabolism Mitogen-Activated Protein Kinases - metabolism Molecular Sequence Data Nuclear factor κB Organ Specificity Protein Structure, Tertiary Proteins - metabolism Receptors, Tumor Necrosis Factor - metabolism Sequence Homology, Amino Acid Signal Transduction Subcellular Fractions - metabolism Subcellular localization Substrate Specificity TNF Receptor-Associated Factor 3 Transfection Tumor necrosis factor receptor Tumor necrosis factor receptor-associated factor 3 Two-Hybrid System Techniques |
| title | T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T08%3A43%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=T3JAM,%20a%20novel%20protein%20that%20specifically%20interacts%20with%20TRAF3%20and%20promotes%20the%20activation%20of%20JNK&rft.jtitle=FEBS%20letters&rft.au=Dadgostar,%20Hajir&rft.date=2003-10-23&rft.volume=553&rft.issue=3&rft.spage=403&rft.epage=407&rft.pages=403-407&rft.issn=0014-5793&rft.eissn=1873-3468&rft_id=info:doi/10.1016/S0014-5793(03)01072-X&rft_dat=%3Cproquest_pubme%3E71300302%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71300302&rft_id=info:pmid/14572659&rft_els_id=S001457930301072X&rfr_iscdi=true |